PDB
9P0M
Resolution
3.0 Å
Released
April 29, 2026
Receptor
CXCR3
Class
A
Species
Homo sapiens
Ligand
CXCL11
Function
Agonist
Reference
10.1126/SCIADV.ADZ3767

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Ligand Amino Acid Generic Number Segment Interaction Type
CXCL11 H8 N-term polar (hydrogen bond)
CXCL11 H8 N-term polar (hydrogen bond with backbone)
CXCL11 Q9 N-term polar (hydrogen bond)
CXCL11 Q9 N-term polar (hydrogen bond with backbone)
CXCL11 V10 N-term polar (hydrogen bond)
CXCL11 L11 N-term polar (hydrogen bond)
CXCL11 L11 N-term polar (hydrogen bond with backbone)
CXCL11 D13 N-term polar (charge-assisted hydrogen bond)
CXCL11 E15 N-term polar (charge-charge)
CXCL11 E15 N-term polar (charge-assisted hydrogen bond)
CXCL11 V16 N-term Van der Waals
CXCL11 L19 N-term polar (hydrogen bond with backbone)
CXCL11 L19 N-term Van der Waals
CXCL11 L20 N-term Van der Waals
CXCL11 F23 N-term polar (hydrogen bond)
CXCL11 S25 N-term polar (hydrogen bond)
CXCL11 S25 N-term polar (hydrogen bond)
CXCL11 S26 N-term polar (hydrogen bond)
CXCL11 Y27 N-term Van der Waals
CXCL11 Y29 N-term polar (hydrogen bond)
CXCL11 C37 N-term polar (hydrogen bond)
CXCL11 C38 N-term polar (hydrogen bond with backbone)
CXCL11 C38 N-term Van der Waals
CXCL11 T39 N-term polar (charge-assisted hydrogen bond)
CXCL11 T39 N-term polar (hydrogen bond)
CXCL11 S40 N-term Van der Waals
CXCL11 P41 N-term polar (hydrogen bond)
CXCL11 P42 N-term polar (hydrogen bond)
CXCL11 C43 N-term Van der Waals
CXCL11 W109 2.60x60 TM2 polar (hydrogen bond)
CXCL11 D112 2.63x63 TM2 polar (charge-assisted hydrogen bond)
CXCL11 D112 2.63x63 TM2 polar (charge-charge)
CXCL11 A113 2.64x64 TM2 Van der Waals
CXCL11 G128 3.29x29 TM3 Van der Waals
CXCL11 F131 3.32x32 TM3 Van der Waals
CXCL11 F131 3.32x32 TM3 aromatic (edge-to-face)
CXCL11 N132 3.33x33 TM3 polar (hydrogen bond)
CXCL11 F135 3.36x36 TM3 aromatic (face-to-edge)
CXCL11 F135 3.36x36 TM3 Van der Waals
CXCL11 L190 4.64x65 TM4 hydrophobic
CXCL11 L190 4.64x65 TM4 Van der Waals
CXCL11 D195 ECL2 polar (charge-assisted hydrogen bond)
CXCL11 R197 ECL2 polar (charge-assisted hydrogen bond)
CXCL11 C203 45.50x50 ECL2 polar (hydrogen bond with backbone)
CXCL11 C203 45.50x50 ECL2 Van der Waals
CXCL11 Q204 45.51x51 ECL2 polar (hydrogen bond)
CXCL11 Q204 45.51x51 ECL2 polar (hydrogen bond)
CXCL11 Y205 45.52x52 ECL2 polar (hydrogen bond)
CXCL11 N206 ECL2 polar (hydrogen bond with backbone)
CXCL11 N206 ECL2 Van der Waals
CXCL11 F207 ECL2 polar (hydrogen bond with backbone)
CXCL11 F207 ECL2 polar (hydrogen bond)
CXCL11 P208 5.31x32 TM5 polar (hydrogen bond)
CXCL11 P208 5.31x32 TM5 polar (hydrogen bond with backbone)
CXCL11 Q209 5.32x33 TM5 polar (hydrogen bond)
CXCL11 Q209 5.32x33 TM5 polar (hydrogen bond)
CXCL11 Q209 5.32x33 TM5 polar (hydrogen bond)
CXCL11 R212 5.35x36 TM5 polar (hydrogen bond with backbone)
CXCL11 R212 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CXCL11 L215 5.38x39 TM5 hydrophobic
CXCL11 L215 5.38x39 TM5 Van der Waals
CXCL11 R216 5.39x40 TM5 polar (charge-assisted hydrogen bond)
CXCL11 Q219 5.42x43 TM5 polar (hydrogen bond)
CXCL11 W268 6.48x48 TM6 Van der Waals
CXCL11 Y271 6.51x51 TM6 polar (charge-assisted hydrogen bond)
CXCL11 Y271 6.51x51 TM6 polar (hydrogen bond)
CXCL11 D278 6.58x58 TM6 polar (charge-assisted hydrogen bond)
CXCL11 D278 6.58x58 TM6 polar (charge-charge)
CXCL11 R288 ECL3 polar (charge-assisted hydrogen bond)
CXCL11 E293 7.28x27 TM7 polar (charge-assisted hydrogen bond)
CXCL11 E293 7.28x27 TM7 polar (charge-charge)
CXCL11 V296 7.31x30 TM7 Van der Waals
CXCL11 D297 7.32x31 TM7 polar (charge-assisted hydrogen bond)
CXCL11 D297 7.32x31 TM7 polar (charge-charge)
CXCL11 K300 7.35x34 TM7 Van der Waals
CXCL11 Y308 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R T A L ICL1ECL1 Q W V F ECL1ICL2 A T Q L Y R R G P P ICL2ECL2 S A H H D E R L N A T H C Q Y N F ECL2ICL3 R G Q ICL3ECL3 A L A R ECL3N-term M V L E V S D H Q V L N D A E V A A L L E N F S S S Y D Y G E N E S D S C C T S P P C P N-termC-term G C P N Q R G L Q R Q P S S S R R D S S W S E T S E A S Y S G L C-term Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A R V T L T C L A V W G L C L L F A L P D F I F L P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K M W M L F R E R L L L R
Helix box plot — Download: PNG | SVG G N G L L G L L F L L S Y L A P L F A R 1 L H L A V A D T L L V L T L P L W A V D 2 C A L L L A G A Y F N I N F L A G A V K 3 V T L T C L A V W G L C L L F A L P D 4 Y C Y A M V L L P L L F G A V L Q L V R L 5 V V V V V A F A L C W T P Y H L V V L V 6 L P N L C C H M Y G L G S T V S K A V 7

GPCRdb(A)
GPCRdb(A)
CXCR3
TM2
2x60 2.60x60 W109
2x63 2.63x63 D112
2x64 2.64x64 A113
TM3
3x29 3.29x29 G128
3x32 3.32x32 F131
3x33 3.33x33 N132
3x36 3.36x36 F135
TM4
4x65 4.64x65 L190
ECL2
45x50 45.50x50 C203
45x51 45.51x51 Q204
45x52 45.52x52 Y205
TM5
5x32 5.31x32 P208
5x33 5.32x33 Q209
5x36 5.35x36 R212
5x39 5.38x39 L215
5x40 5.39x40 R216
5x43 5.42x43 Q219
TM6
6x48 6.48x48 W268
6x51 6.51x51 Y271
6x58 6.58x58 D278
TM7
7x27 7.28x27 E293
7x30 7.31x30 V296
7x31 7.32x31 D297
7x34 7.35x34 K300
7x42 7.43x42 Y308