PDB
9P93
Resolution
3.2 Å
Released
Nov. 19, 2025
Receptor
PAC1
Class
B1
Species
Homo sapiens
Ligand
Vasoactive intestinal polypeptide
Function
Agonist
Reference
10.1073/PNAS.2521157122

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Ligand Amino Acid Generic Number Segment Interaction Type
Vasoactive intestinal polypeptide I83 N-term Van der Waals
Vasoactive intestinal polypeptide I83 N-term polar (hydrogen bond with backbone)
Vasoactive intestinal polypeptide F84 N-term Van der Waals
Vasoactive intestinal polypeptide Q146 1.32x32 TM1 Van der Waals
Vasoactive intestinal polypeptide D147 1.33x33 TM1 Van der Waals
Vasoactive intestinal polypeptide Y150 1.36x36 TM1 Van der Waals
Vasoactive intestinal polypeptide Y150 1.36x36 TM1 hydrophobic
Vasoactive intestinal polypeptide V153 1.39x39 TM1 hydrophobic
Vasoactive intestinal polypeptide V153 1.39x39 TM1 Van der Waals
Vasoactive intestinal polypeptide K154 1.40x40 TM1 Van der Waals
Vasoactive intestinal polypeptide Y157 1.43x43 TM1 Van der Waals
Vasoactive intestinal polypeptide Y157 1.43x43 TM1 hydrophobic
Vasoactive intestinal polypeptide Y161 1.47x47 TM1 Van der Waals
Vasoactive intestinal polypeptide R199 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Vasoactive intestinal polypeptide K206 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Vasoactive intestinal polypeptide L210 2.71x71 TM2 Van der Waals
Vasoactive intestinal polypeptide Y211 2.72x72 TM2 aromatic (face-to-edge)
Vasoactive intestinal polypeptide Y211 2.72x72 TM2 Van der Waals
Vasoactive intestinal polypeptide F233 3.36x36 TM3 Van der Waals
Vasoactive intestinal polypeptide F233 3.36x36 TM3 hydrophobic
Vasoactive intestinal polypeptide H234 3.37x37 TM3 aromatic (face-to-edge)
Vasoactive intestinal polypeptide H234 3.37x37 TM3 Van der Waals
Vasoactive intestinal polypeptide V237 3.40x40 TM3 Van der Waals
Vasoactive intestinal polypeptide V237 3.40x40 TM3 hydrophobic
Vasoactive intestinal polypeptide Y241 3.44x44 TM3 Van der Waals
Vasoactive intestinal polypeptide D298 45.52x52 ECL2 Van der Waals
Vasoactive intestinal polypeptide M299 ECL2 hydrophobic
Vasoactive intestinal polypeptide M299 ECL2 Van der Waals
Vasoactive intestinal polypeptide N300 ECL2 polar (hydrogen bond with backbone)
Vasoactive intestinal polypeptide N300 ECL2 Van der Waals
Vasoactive intestinal polypeptide W306 5.36x37 TM5 Van der Waals
Vasoactive intestinal polypeptide W306 5.36x37 TM5 hydrophobic
Vasoactive intestinal polypeptide E374 ECL3 Van der Waals
Vasoactive intestinal polypeptide K378 7.35x34 TM7 Van der Waals
Vasoactive intestinal polypeptide R381 7.38x37 TM7 Van der Waals
Vasoactive intestinal polypeptide L382 7.39x38 TM7 Van der Waals
Vasoactive intestinal polypeptide L382 7.39x38 TM7 hydrophobic
Vasoactive intestinal polypeptide E385 7.42x41 TM7 Van der Waals
Vasoactive intestinal polypeptide L386 7.43x42 TM7 Van der Waals
Vasoactive intestinal polypeptide L386 7.43x42 TM7 hydrophobic

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ICL1 R K L H ICL1ECL1 Y A E Q D S N H C F I S ECL1ICL2 T F F P E R ICL2ECL2 D T G C W D M N D ECL2ICL3 Q S P D M G G ICL3ECL3 P E N V S ECL3N-term M A G V V H V S L A A L L L L P M A P A M H S D C I F K K E Q A M C L E K I Q R A N E L M G F N D S S P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q V W E T E T I G E S D F G D S N S L D L S D M G V V S R N C T E D G W S E P F P H Y F D A C G F D E N-termC-term H R H P S L A S S G V N G G T Q L S I L S K S S S Q I R M S G L P A D N L A T C-term Y E S E T G D Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F C T R N F I H M N L F V S F M L R A I S V F I K D W I L T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L N E S S I Y L R L A R S T L L L I P L F G I H Y T V F A F S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E I K R W K V A V D V Q A E K W R S N R Y F F K
Helix box plot — Download: PNG | SVG T L T V L S T S Y G V T Y L A K V S L Y 1 M N L F V S F M L R A I S V F I K D W I 2 I F L W F Y N S V V C Y H F F V M V A K 3 Y F Y W Y T I G I W G T P T V C V T V W A 4 F L V F N V M I S G V V P G K I V W W L A 5 L L L I P L F G I H Y T V F A F S 6 V A V V F G Q F S G L G L E F V L R E 7

GPCRdb(A)
GPCRdb(B)
PAC1 receptor
TM1
1x28 1.32x32 Q146
1x29 1.33x33 D147
1x32 1.36x36 Y150
1x35 1.39x39 V153
1x36 1.40x40 K154
1x39 1.43x43 Y157
1x43 1.47x47 Y161
TM2
2x53 2.60x60 R199
2x60 2.67x67 K206
2x64 2.71x71 L210
TM3
3x32 3.36x36 F233
3x33 3.37x37 H234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 D298
TM5
5x41 5.36x37 W306
TM7
7x30 7.35x34 K378
7x33 7.38x37 R381
7x34 7.39x38 L382
7x37 7.42x41 E385
7x38 7.43x42 L386