PDB
9PLN
Resolution
2.8 Å
Released
Aug. 20, 2025
Receptor
α2A
Class
A
Species
Homo sapiens
Ligand
N-(5-methylnaphthalen-1-yl)pyridin-4-amine
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
N-(5-methylnaphthalen-1-yl)pyridin-4-amine D128 3.32x32 TM3 polar (charge-assisted hydrogen bond)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine V129 3.33x33 TM3 Van der Waals
N-(5-methylnaphthalen-1-yl)pyridin-4-amine V129 3.33x33 TM3 hydrophobic
N-(5-methylnaphthalen-1-yl)pyridin-4-amine C132 3.36x36 TM3 polar (hydrogen bond)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine T133 3.37x37 TM3 Van der Waals
N-(5-methylnaphthalen-1-yl)pyridin-4-amine T133 3.37x37 TM3 polar (hydrogen bond with backbone)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine I205 45.52x52 ECL2 Van der Waals
N-(5-methylnaphthalen-1-yl)pyridin-4-amine S215 5.42x43 TM5 polar (hydrogen bond)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine S215 5.42x43 TM5 polar (hydrogen bond with backbone)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine C216 5.43x44 TM5 Van der Waals
N-(5-methylnaphthalen-1-yl)pyridin-4-amine S219 5.46x461 TM5 polar (hydrogen bond)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine W402 6.48x48 TM6 polar (hydrogen bond)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine F405 6.51x51 TM6 Van der Waals
N-(5-methylnaphthalen-1-yl)pyridin-4-amine F405 6.51x51 TM6 aromatic (face-to-edge)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine F406 6.52x52 TM6 aromatic (edge-to-face)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine F406 6.52x52 TM6 Van der Waals
N-(5-methylnaphthalen-1-yl)pyridin-4-amine Y409 6.55x55 TM6 polar (hydrogen bond)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine F427 7.39x38 TM7 aromatic (edge-to-face)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine F427 7.39x38 TM7 polar (hydrogen bond with backbone)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine F427 7.39x38 TM7 polar (hydrogen bond)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine G430 7.42x41 TM7 polar (hydrogen bond)
N-(5-methylnaphthalen-1-yl)pyridin-4-amine Y431 7.43x42 TM7 polar (hydrogen bond)

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ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
Helix box plot — Download: PNG | SVG V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7

GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x32 3.32x32 D128
3x33 3.33x33 V129
3x36 3.36x36 C132
3x37 3.37x37 T133
ECL2
45x52 45.52x52 I205
TM5
5x43 5.42x43 S215
5x44 5.43x44 C216
5x461 5.46x461 S219
TM6
6x48 6.48x48 W402
6x51 6.51x51 F405
6x52 6.52x52 F406
6x55 6.55x55 Y409
TM7
7x38 7.39x38 F427
7x41 7.42x41 G430
7x42 7.43x42 Y431