PDB
9PPQ
Resolution
3.3 Å
Released
March 4, 2026
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
0505
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
0505 Q126 2.60x60 TM2 polar (hydrogen bond)
0505 N129 2.63x63 TM2 Van der Waals
0505 W135 23.50x50 ECL1 hydrophobic
0505 W135 23.50x50 ECL1 Van der Waals
0505 V145 3.28x28 TM3 Van der Waals
0505 I146 3.29x29 TM3 polar (hydrogen bond)
0505 D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
0505 Y150 3.33x33 TM3 polar (hydrogen bond)
0505 M153 3.36x36 TM3 polar (hydrogen bond)
0505 C219 45.50x50 ECL2 Van der Waals
0505 K235 5.39x40 TM5 Van der Waals
0505 V238 5.42x43 TM5 hydrophobic
0505 V238 5.42x43 TM5 Van der Waals
0505 W295 6.48x48 TM6 Van der Waals
0505 I298 6.51x51 TM6 hydrophobic
0505 I298 6.51x51 TM6 Van der Waals
0505 H299 6.52x52 TM6 polar (hydrogen bond)
0505 V302 6.55x55 TM6 polar (hydrogen bond)
0505 I324 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q126
2x63 2.63x63 N129
ECL1
23x50 23.50x50 W135
TM3
3x28 3.28x28 V145
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
ECL2
45x50 45.50x50 C219
TM5
5x40 5.39x40 K235
5x43 5.42x43 V238
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
6x55 6.55x55 V302
TM7
7x38 7.39x38 I324