PDB
9PQD
Resolution
3.3 Å
Released
Aug. 20, 2025
Receptor
α2A
Class
A
Species
Homo sapiens
Ligand
z7149
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
z7149 D128 3.32x32 TM3 polar (charge-assisted hydrogen bond)
z7149 V129 3.33x33 TM3 Van der Waals
z7149 V129 3.33x33 TM3 hydrophobic
z7149 C132 3.36x36 TM3 Van der Waals
z7149 C132 3.36x36 TM3 hydrophobic
z7149 T133 3.37x37 TM3 Van der Waals
z7149 S215 5.42x43 TM5 Van der Waals
z7149 C216 5.43x44 TM5 hydrophobic
z7149 C216 5.43x44 TM5 Van der Waals
z7149 S219 5.46x461 TM5 Van der Waals
z7149 W402 6.48x48 TM6 hydrophobic
z7149 W402 6.48x48 TM6 Van der Waals
z7149 F405 6.51x51 TM6 aromatic (edge-to-face)
z7149 F405 6.51x51 TM6 Van der Waals
z7149 F406 6.52x52 TM6 aromatic (edge-to-face)
z7149 F406 6.52x52 TM6 Van der Waals
z7149 Y409 6.55x55 TM6 hydrophobic
z7149 Y409 6.55x55 TM6 Van der Waals
z7149 F427 7.39x38 TM7 Van der Waals
z7149 F427 7.39x38 TM7 hydrophobic
z7149 Y431 7.43x42 TM7 polar (hydrogen bond)

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ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
Helix box plot — Download: PNG | SVG V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7

GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x32 3.32x32 D128
3x33 3.33x33 V129
3x36 3.36x36 C132
3x37 3.37x37 T133
TM5
5x43 5.42x43 S215
5x44 5.43x44 C216
5x461 5.46x461 S219
TM6
6x48 6.48x48 W402
6x51 6.51x51 F405
6x52 6.52x52 F406
6x55 6.55x55 Y409
TM7
7x38 7.39x38 F427
7x42 7.43x42 Y431