PDB
9PXX
Resolution
3.1 Å
Released
Nov. 12, 2025
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
naloxone
Function
Agonist (partial)
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
naloxone D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
naloxone Y150 3.33x33 TM3 Van der Waals
naloxone Y150 3.33x33 TM3 polar (hydrogen bond)
naloxone V238 5.42x43 TM5 hydrophobic
naloxone V238 5.42x43 TM5 Van der Waals
naloxone I298 6.51x51 TM6 hydrophobic
naloxone I298 6.51x51 TM6 Van der Waals
naloxone H299 6.52x52 TM6 Van der Waals
naloxone V302 6.55x55 TM6 hydrophobic
naloxone V302 6.55x55 TM6 Van der Waals
naloxone W320 7.35x34 TM7 Van der Waals
naloxone W320 7.35x34 TM7 hydrophobic
naloxone I324 7.39x38 TM7 hydrophobic
naloxone I324 7.39x38 TM7 Van der Waals
naloxone Y328 7.43x42 TM7 hydrophobic
naloxone Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x32 3.32x32 D149
3x33 3.33x33 Y150
TM5
5x43 5.42x43 V238
TM6
6x51 6.51x51 I298
6x52 6.52x52 H299
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328