PDB
9PY2
Resolution
3.2 Å
Released
Nov. 12, 2025
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
loperamide
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
loperamide W135 23.50x50 ECL1 hydrophobic
loperamide V145 3.28x28 TM3 hydrophobic
loperamide I146 3.29x29 TM3 hydrophobic
loperamide Y150 3.33x33 TM3 hydrophobic
loperamide M153 3.36x36 TM3 hydrophobic
loperamide F154 3.37x37 TM3 hydrophobic
loperamide V238 5.42x43 TM5 hydrophobic
loperamide W295 6.48x48 TM6 hydrophobic
loperamide Y328 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
ECL1
23x50 23.50x50 W135
TM3
3x28 3.28x28 V145
3x29 3.29x29 I146
3x33 3.33x33 Y150
3x36 3.36x36 M153
3x37 3.37x37 F154
TM5
5x43 5.42x43 V238
TM6
6x48 6.48x48 W295
TM7
7x42 7.43x42 Y328