PDB
9QP4
Resolution
3.1 Å
Released
June 24, 2026
Receptor
OPN1SW
Class
A
Species
Homo sapiens
Ligand
all-trans-retinal
Function
Inverse agonist
Reference
10.1126/SCIENCE.ADZ3624

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Ligand Amino Acid Generic Number Segment Interaction Type
all-trans-retinal P183 45.52x52 ECL2 hydrophobic
all-trans-retinal F202 5.43x44 TM5 hydrophobic
all-trans-retinal C205 5.46x461 TM5 hydrophobic
all-trans-retinal F206 5.47x47 TM5 hydrophobic
all-trans-retinal Y259 6.48x48 TM6 hydrophobic
all-trans-retinal Y262 6.51x51 TM6 hydrophobic
all-trans-retinal A263 6.52x52 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 Y F V F ECL1ICL2 P F G N F R F ICL2ECL2 W S R F I P E G L Q C S C G P D W Y T V G T K Y ECL2ICL3 Q E ICL3ECL3 R N H G L ECL3N-term M S E E E F Y L F K N I S S V G P W D G P Q Y H I A N-termC-term G K A M T D E S D T C S S Q K T E V S T V S S T Q V G P N C-term P V W A F Y L Q A A F M G T V F L I G F P L N A M V L V A T L R Y Q P L N Y I L V N V S F G G F L L C I F S V F P V F V A S C N G G R H V C A L E G F L G T V A G L V T G W S L A F L A F E R Y I V I C K S S K H A L T V V L A T W T I G I G V S I P P F F G R S E S Y T W F L F I F C F I V P L S L I C F S Y T Q L L R A L K A V A A Q Q S A T T Q K A E R E V S R M V V V M V G S F C V C Y V P Y A A F A M Y M V N N D L R L V T I P S F F S K S A C I Y N P I I Y C F M N K Q I M K F Q A C M V C
Helix box plot — Download: PNG | SVG A N L P F G I L F V T G M F A A Q L Y F 1 V N V S F G G F L L C F I S V F P V F V A 2 F A L S W G T V L G A V T G L F G E L A 3 A L T V V L A T W T I G I G V S I P P F 4 Y S F C I L S L P V I F C F I F L F W T Y 5 V V M V G S F C V C Y V P Y A A F A M Y 6 I P N Y I C A S K S F F S P I T V L R 7

GPCRdb(A)
GPCRdb(A)
OPN1SW
ECL2
45x52 45.52x52 P183
TM5
5x44 5.43x44 F202
5x461 5.46x461 C205
5x47 5.47x47 F206
TM6
6x48 6.48x48 Y259
6x51 6.51x51 Y262
6x52 6.52x52 A263