PDB
9RHG
Resolution
2.5 Å
Released
Dec. 24, 2025
Receptor
FZD7
Class
F
Species
Homo sapiens
Ligand
Function
C407
NAM
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
C407 Y296 2.51x51 TM2 hydrophobic
C407 V299 2.54x54 TM2 Van der Waals
C407 H303 2.58x58 TM2 Van der Waals
C407 L343 3.32x32 TM3 Van der Waals
C407 G347 3.36x36 TM3 Van der Waals
C407 S350 3.39x39 TM3 Van der Waals
C407 S351 3.40x40 TM3 Van der Waals
C407 D405 ECL2 hydrophobic
C407 S408 ECL2 Van der Waals
C407 V410 ECL2 Van der Waals
C407 Y412 45.51x51 ECL2 hydrophobic
C407 L415 ECL2 hydrophobic
C407 Y489 6.51x51 TM6 polar (hydrogen bond)
C407 Y489 6.51x51 TM6 hydrophobic
C407 F530 7.38x38 TM7 hydrophobic
C407 K533 7.41x41 TM7 Van der Waals
C407 Y534 7.42x42 TM7 hydrophobic
C407 Y534 7.42x42 TM7 aromatic (edge-to-face)
C407 T537 7.45x45 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M R R F S ICL1ECL1 E D R A V C V E R F S D D G Y R T V A Q G T K K E ECL1ICL2 M K W ICL2ECL2 Q V D G D L L S G V C Y V G L S ECL2ICL3 H D G T ICL3ECL3 V P C P P G H F P P M S P ECL3N-term M R D P G A A A P L S S L G L C A L V L A L L G A L S A G A G A Q P Y H G E K G I S V P D H G F C Q P I S I P L C T D I A Y N Q T I L P N L L G H T N Q E D A G L E V H Q F Y P L V K V Q C S P E L R F F L C S M Y A P V C T V L D Q A I P P C R S L C E R A R Q G C E A L M N K F G F Q W P E R L R C E N F P V H G A G E I C V G Q N T S D G S G G P G G G P T A Y P T A P Y L P D L P F T A L P P G A S D G R G R P A F P F S C P R Q L K V P P Y L G Y R F L G E R D C G A P C E P G R A N G L M Y N-termC-term S S K G E T A V C-term F K E E E R R F A R L W V G V W S V L C C A S T L F T V L T Y L V D Y P E R P I I F L S G C Y F M V A V A H V A G F L L G C T I L F M V L Y F F G M A S S I W W V I L S L T W F L A A G G H E A I E A N S Q Y F H L A A W A V P A V K T I T I L A M G S V D A L R G F V L A P L F V Y L F I G T S F L L A G F V S L F R I R T I M K K T E K L E K L M V R I G V F S V L Y T V P A T I V L A C Y F Y E Q A F R E H W E R T W L L Q T C K S Y A D F T V F M I K Y L M T M I V G I T T G F W I W S G K W R R L S H T L Q S F Y H R
Helix box plot — Download: PNG | SVG L T S A C C L V S W V G V W L R A F R R 1 I F L S G C Y F M V A V A H V A G F L L 2 I V W W I S S A M G F F Y L V M F L I T 3 S Q Y F H L A A W A V P A V K T I T I L 4 L F S T G I F L Y V F L P A L V F G R L A 5 G V F S V L Y T V P A T I V L A C Y F Y 6 F G T T I G V I M T M L Y K I M F V T F 7

GPCRdb(A)
GPCRdb(F)
FZD7
TM2
2x50 2.51x51 Y296
2x53 2.54x54 V299
2x57 2.58x58 H303
TM3
3x32 3.32x32 L343
3x36 3.36x36 G347
3x39 3.39x39 S350
3x40 3.40x40 S351
ECL2
45x51 45.51x51 Y412
TM6
6x55 6.51x51 Y489
TM7
7x35 7.38x38 F530
7x38 7.41x41 K533
7x39 7.42x42 Y534
7x42 7.45x45 T537