PDB
9RHG
Resolution
2.5 Å
Released
Dec. 24, 2025
Receptor
FZD7
Class
F
Species
Homo sapiens
Ligand
C407
Function
NAM
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
C407 Y296 2.51x51 TM2 hydrophobic
C407 L343 3.32x32 TM3 hydrophobic
C407 D405 ECL2 polar (charge-assisted hydrogen bond)
C407 S408 ECL2 Van der Waals
C407 Y412 45.51x51 ECL2 Van der Waals
C407 Y412 45.51x51 ECL2 polar (hydrogen bond)
C407 L415 ECL2 hydrophobic
C407 L415 ECL2 Van der Waals
C407 Y489 6.51x51 TM6 polar (hydrogen bond)
C407 Y489 6.51x51 TM6 Van der Waals
C407 F530 7.38x38 TM7 hydrophobic
C407 F530 7.38x38 TM7 Van der Waals
C407 K533 7.41x41 TM7 polar (charge-assisted hydrogen bond)
C407 Y534 7.42x42 TM7 aromatic (edge-to-face)
C407 Y534 7.42x42 TM7 polar (hydrogen bond)
C407 Y534 7.42x42 TM7 polar (hydrogen bond)
C407 T537 7.45x45 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 M R R F S ICL1ECL1 E D R A V C V E R F S D D G Y R T V A Q G T K K E ECL1ICL2 M K W ICL2ECL2 Q V D G D L L S G V C Y V G L S ECL2ICL3 H D G T ICL3ECL3 V P C P P G H F P P M S P ECL3N-term M R D P G A A A P L S S L G L C A L V L A L L G A L S A G A G A Q P Y H G E K G I S V P D H G F C Q P I S I P L C T D I A Y N Q T I L P N L L G H T N Q E D A G L E V H Q F Y P L V K V Q C S P E L R F F L C S M Y A P V C T V L D Q A I P P C R S L C E R A R Q G C E A L M N K F G F Q W P E R L R C E N F P V H G A G E I C V G Q N T S D G S G G P G G G P T A Y P T A P Y L P D L P F T A L P P G A S D G R G R P A F P F S C P R Q L K V P P Y L G Y R F L G E R D C G A P C E P G R A N G L M Y N-termC-term S S K G E T A V C-term F K E E E R R F A R L W V G V W S V L C C A S T L F T V L T Y L V D Y P E R P I I F L S G C Y F M V A V A H V A G F L L G C T I L F M V L Y F F G M A S S I W W V I L S L T W F L A A G G H E A I E A N S Q Y F H L A A W A V P A V K T I T I L A M G S V D A L R G F V L A P L F V Y L F I G T S F L L A G F V S L F R I R T I M K K T E K L E K L M V R I G V F S V L Y T V P A T I V L A C Y F Y E Q A F R E H W E R T W L L Q T C K S Y A D F T V F M I K Y L M T M I V G I T T G F W I W S G K W R R L S H T L Q S F Y H R
Helix box plot — Download: PNG | SVG L T S A C C L V S W V G V W L R A F R R 1 I F L S G C Y F M V A V A H V A G F L L 2 I V W W I S S A M G F F Y L V M F L I T 3 S Q Y F H L A A W A V P A V K T I T I L 4 L F S T G I F L Y V F L P A L V F G R L A 5 G V F S V L Y T V P A T I V L A C Y F Y 6 F G T T I G V I M T M L Y K I M F V T F 7

GPCRdb(A)
GPCRdb(F)
FZD7
TM2
2x50 2.51x51 Y296
TM3
3x32 3.32x32 L343
ECL2
45x51 45.51x51 Y412
TM6
6x55 6.51x51 Y489
TM7
7x35 7.38x38 F530
7x38 7.41x41 K533
7x39 7.42x42 Y534
7x42 7.45x45 T537