PDB
9U80
Resolution
2.9 Å
Released
Dec. 10, 2025
Receptor
V2
Class
A
Species
Homo sapiens
Ligand
Function
conivaptan
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
conivaptan W99 2.64x63 TM2 Van der Waals
conivaptan F105 23.50x50 ECL1 hydrophobic
conivaptan K116 3.29x29 TM3 Van der Waals
conivaptan Q119 3.32x32 TM3 Van der Waals
conivaptan M120 3.33x33 TM3 Van der Waals
conivaptan M123 3.36x36 TM3 Van der Waals
conivaptan F178 ECL2 hydrophobic
conivaptan C192 45.50x50 ECL2 Van der Waals
conivaptan R202 5.35x36 TM5 Van der Waals
conivaptan Y205 5.38x39 TM5 hydrophobic
conivaptan V206 5.39x40 TM5 Van der Waals
conivaptan I209 5.42x43 TM5 hydrophobic
conivaptan F287 6.51x51 TM6 hydrophobic
conivaptan Q291 6.55x55 TM6 Van der Waals
conivaptan F307 ECL3 hydrophobic
conivaptan M311 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
Helix box plot — Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7

GPCRdb(A)
GPCRdb(A)
V2 receptor
TM2
2x63 2.64x63 W99
ECL1
23x50 23.50x50 F105
TM3
3x29 3.29x29 K116
3x32 3.32x32 Q119
3x33 3.33x33 M120
3x36 3.36x36 M123
ECL2
45x50 45.50x50 C192
TM5
5x36 5.35x36 R202
5x39 5.38x39 Y205
5x40 5.39x40 V206
5x43 5.42x43 I209
TM6
6x51 6.51x51 F287
6x55 6.55x55 Q291
TM7
7x38 7.39x38 M311