PDB
9UGL
Resolution
2.7 Å
Released
April 15, 2026
Receptor
5-HT2C
Class
A
Species
Homo sapiens
Ligand
SB 242084
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
SB 242084 I114 2.65x64 TM2 hydrophobic
SB 242084 Y118 ECL1 aromatic (edge-to-face)
SB 242084 D134 3.32x32 TM3 polar (charge-assisted hydrogen bond)
SB 242084 V135 3.33x33 TM3 hydrophobic
SB 242084 V135 3.33x33 TM3 Van der Waals
SB 242084 S138 3.36x36 TM3 Van der Waals
SB 242084 V208 45.51x51 ECL2 Van der Waals
SB 242084 V208 45.51x51 ECL2 hydrophobic
SB 242084 L209 45.52x52 ECL2 hydrophobic
SB 242084 V215 5.39x40 TM5 hydrophobic
SB 242084 V215 5.39x40 TM5 Van der Waals
SB 242084 G218 5.42x43 TM5 Van der Waals
SB 242084 S219 5.43x44 TM5 Van der Waals
SB 242084 F327 6.51x51 TM6 aromatic (edge-to-face)
SB 242084 F327 6.51x51 TM6 Van der Waals
SB 242084 F328 6.52x52 TM6 Van der Waals
SB 242084 F328 6.52x52 TM6 hydrophobic
SB 242084 N331 6.55x55 TM6 Van der Waals
SB 242084 N351 7.36x35 TM7 polar (hydrogen bond)
SB 242084 N351 7.36x35 TM7 Van der Waals
SB 242084 V354 7.39x38 TM7 Van der Waals
SB 242084 V354 7.39x38 TM7 hydrophobic

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ICL1 K K L H ICL1ECL1 Y V W P L ECL1ICL2 P I E H S R F N ICL2ECL2 E E K V F V N N T T C V L N ECL2ICL3 G H T E E P P G L S L D F L K C C K R N T A E E E N S A N P N Q D Q N A R R R K K K E R R P R G T ICL3ECL3 E K S C ECL3N-term M V N L R N A V H S F L V H L I G L L V W Q S D I S V S P V A A I V T D I F N T S D G G R F K F P D G V Q N-termC-term N Y K V E K K P P V R Q I P R V A A T A L S G R E L N V N I Y R H T N E P V I E K A S D N E P G I E M Q V E N L E L P V N P S S V V S E R I S S V C-term N W P A L S I V I I I I M T I G G N I L V I M A V S M E N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D P R Y L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M L L H M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I F S N Y R R A Y L R C
Helix box plot — Download: PNG | SVG I N G G I T M I I I I V I S L A P W N 1 M S L A I A D M L V G L L V M P L S L L A 2 A C L H M I S A T S F L V D L S I W V P 3 A I M K I A I V W A I S I G V S V P I 4 Y T I V M I T L P I F F A V F S G I L V F 5 G I V F F V F L I M W C P F F I T N I L 6 L P N I G S C V Y G I W V F V N L L K 7

GPCRdb(A)
GPCRdb(A)
5-HT2C receptor
TM2
2x64 2.65x64 I114
TM3
3x32 3.32x32 D134
3x33 3.33x33 V135
3x36 3.36x36 S138
ECL2
45x51 45.51x51 V208
45x52 45.52x52 L209
TM5
5x40 5.39x40 V215
5x43 5.42x43 G218
5x44 5.43x44 S219
TM6
6x51 6.51x51 F327
6x52 6.52x52 F328
6x55 6.55x55 N331
TM7
7x35 7.36x35 N351
7x38 7.39x38 V354