PDB
9UMJ
Resolution
3.4 Å
Released
Nov. 26, 2025
Receptor
C3a
Class
A
Species
Mus musculus
Ligand
EP54
Function
Agonist
Reference
10.1101/2025.05.26.656101

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Ligand Amino Acid Generic Number Segment Interaction Type
EP54 I102 3.32x32 TM3 hydrophobic
EP54 I165 ECL2 hydrophobic
EP54 I171 ECL2 hydrophobic
EP54 Y174 45.52x52 ECL2 hydrophobic
EP54 R333 5.42x43 TM5 polar (charge-assisted hydrogen bond)
EP54 Y386 6.51x51 TM6 polar (hydrogen bond)
EP54 Y386 6.51x51 TM6 polar (hydrogen bond)
EP54 G390 6.55x55 TM6 Van der Waals
EP54 D410 7.35x34 TM7 polar (charge-assisted hydrogen bond)
EP54 H411 7.36x35 TM7 Van der Waals
EP54 S413 7.38x37 TM7 polar (hydrogen bond)
EP54 I414 7.39x38 TM7 Van der Waals
EP54 I414 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M K T ICL1ECL1 G H W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 D L F I M D N R S I C R Y N F D S S R S Y D Y W D Y V Y K L S L P E S N S T D N S T A Q L T G H M N D R S A P S S V Q A R D Y F W T V T T A L Q S Q P F L T S P E D S F S L D S A N Q Q P H Y G G K P P N V L T A A V P S G F P V E D R K S N T L N A D A F L S A H T E L F P T A S S G H L Y P Y D F Q G D Y V D Q F T Y D N H ECL2ICL3 T N F T K S R ICL3ECL3 D P E ECL3N-term M E S F D A D T N S T D L H S R P L F N-termC-term S I K G I L E A A F S E E L T H S T N C T Q D K A S S K R N N M S T D V C-term Q P Q D I A S M V I L G L T C L L G L L G N G L V L W V A G V K T V N T V W F L H L T L A D F L C C L S L P F S L A H L I L Q G L F L C K L I P S I I I L N M F A S V F L L T A I S L D R C L I V H K N V R T A F A I C G C V W V V A F V M C V P V F V Y R V P T P L M A I T I T R L V V G F L V P F F I M V I C Y S L I V F R M R K N K T F R V A V A V V T V F F I C W T P Y H L V G V L L L I T S S L G E A V M S W D H M S I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G L L G L L C T L G L I V M S A I D 1 L H L T L A D F L C C L S L P F S L A H 2 A T L L F V S A F M N L I I I S P I L K 3 A F A I C G C V W V V A F V M C V P V 4 Y C I V M I F F P V L F G V V L R T I T I 5 V A V V T V F F I C W T P Y H L V G V L 6 F P N F C S N A S A L A I S M H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM3
3x32 3.32x32 I102
ECL2
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R333
TM6
6x51 6.51x51 Y386
6x55 6.55x55 G390
TM7
7x34 7.35x34 D410
7x35 7.36x35 H411
7x37 7.38x37 S413
7x38 7.39x38 I414