PDB
9UPM
Resolution
3.2 Å
Released
June 24, 2026
Receptor
OPN1LW
Class
A
Species
Macaca fascicularis
Ligand
Function
all-trans-retinal
Inverse agonist
Reference
10.1126/SCIENCE.ADZ3996

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Ligand Amino Acid Generic Number Segment Interaction Type
all-trans-retinal S134 3.33x33 TM3 Van der Waals
all-trans-retinal G137 3.36x36 TM3 Van der Waals
all-trans-retinal I138 3.37x37 TM3 hydrophobic
all-trans-retinal L141 3.40x40 TM3 hydrophobic
all-trans-retinal M220 5.39x40 TM5 Van der Waals
all-trans-retinal L223 5.42x43 TM5 Van der Waals
all-trans-retinal M224 5.43x44 TM5 hydrophobic
all-trans-retinal C227 5.46x461 TM5 Van der Waals
all-trans-retinal C228 5.47x47 TM5 hydrophobic
all-trans-retinal L232 5.51x51 TM5 hydrophobic
all-trans-retinal Y359 6.44x44 TM6 hydrophobic
all-trans-retinal C360 6.45x45 TM6 hydrophobic
all-trans-retinal W363 6.48x48 TM6 hydrophobic
all-trans-retinal G364 6.49x49 TM6 Van der Waals
all-trans-retinal Y366 6.51x51 TM6 hydrophobic
all-trans-retinal T367 6.52x52 TM6 hydrophobic
all-trans-retinal F368 6.53x53 TM6 Van der Waals

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ICL1 K K L R ICL1ECL1 Y F V ECL1ICL2 P F G N V R F ICL2ECL2 P P I F G W S R Y W P H G L K T S C G P D V F S G S S ECL2ICL3 K E ICL3ECL3 P G Y A F ECL3N-term M A Q Q W S L Q R L A G R H P Q D S Y E D S T Q S S I F T Y T N S N S T R G P F E G P N Y H I A N-termC-term G K K V D D G S E L S S A S K T E V S S V S S V S P A C-term P R W V Y H L T S V W M I F V V T A S V F T N G L V L A A T M K F H P L N W I L V N L A V A D L A E T V I A S T I S V V N Q V S G L G H P M C V L E G F T V S L C G I T G L W S L A I I S W E R W L V V C K D A K L A I V G I A F S W I W S A V W T A Y P G V Q S Y M I V L M V T C C I I P L A I I V L C Y L Q V W L A I R A V A K Q Q S E S T Q K A E K E V T R M V M V M I F A Y C V C W G P Y T F F A C F A A A N H P L M A A L P A Y F A K S A T I Y N P I I Y V F M N R Q F L Q L R N C I F
Helix box plot — Download: PNG | SVG G N T F V S A T V V F I M W V S T L H Y 1 V N L A V A D L A E T I V A S T I S V V N 2 I A L S W L G T I G C L S V T F G E L V 3 A I V G I A F S W I W S A V W T A 4 Y C L V I I A L P I I C C T V M L V I M Y 5 M V M I F A Y C V C W G P Y T F F A C F 6 I P N Y I T A S K A F Y A P L A A M L 7

GPCRdb(A)
GPCRdb(A)
OPN1LW
TM3
3x33 3.33x33 S134
3x36 3.36x36 G137
3x37 3.37x37 I138
3x40 3.40x40 L141
TM5
5x40 5.39x40 M220
5x43 5.42x43 L223
5x44 5.43x44 M224
5x461 5.46x461 C227
5x47 5.47x47 C228
5x51 5.51x51 L232
TM6
6x44 6.44x44 Y277
6x45 6.45x45 C278
6x48 6.48x48 W281
6x49 6.49x49 G282
6x51 6.51x51 Y284
6x52 6.52x52 T285
6x53 6.53x53 F286