PDB
9UVV
Resolution
3.0 Å
Released
May 6, 2026
Receptor
V2
Class
A
Species
Homo sapiens
Ligand
CHEMBL4303142
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4303142 Q92 2.57x56 TM2 polar (hydrogen bond)
CHEMBL4303142 Q92 2.57x56 TM2 Van der Waals
CHEMBL4303142 V93 2.58x57 TM2 hydrophobic
CHEMBL4303142 V93 2.58x57 TM2 Van der Waals
CHEMBL4303142 K116 3.29x29 TM3 polar (charge-assisted hydrogen bond)
CHEMBL4303142 Q119 3.32x32 TM3 Van der Waals
CHEMBL4303142 M120 3.33x33 TM3 Van der Waals
CHEMBL4303142 M120 3.33x33 TM3 hydrophobic
CHEMBL4303142 M123 3.36x36 TM3 hydrophobic
CHEMBL4303142 M123 3.36x36 TM3 Van der Waals
CHEMBL4303142 Q174 4.60x61 TM4 Van der Waals
CHEMBL4303142 F178 4.64x65 TM4 Van der Waals
CHEMBL4303142 F196 ECL2 hydrophobic
CHEMBL4303142 R202 ECL2 Van der Waals
CHEMBL4303142 Y205 5.38x39 TM5 hydrophobic
CHEMBL4303142 V206 5.39x40 TM5 hydrophobic
CHEMBL4303142 V206 5.39x40 TM5 Van der Waals
CHEMBL4303142 I209 5.42x43 TM5 Van der Waals
CHEMBL4303142 I209 5.42x43 TM5 hydrophobic
CHEMBL4303142 W362 6.48x48 TM6 hydrophobic
CHEMBL4303142 F365 6.51x51 TM6 hydrophobic
CHEMBL4303142 F365 6.51x51 TM6 Van der Waals
CHEMBL4303142 F366 6.52x52 TM6 Van der Waals
CHEMBL4303142 Q369 6.55x55 TM6 Van der Waals
CHEMBL4303142 M389 7.39x38 TM7 hydrophobic
CHEMBL4303142 M389 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
Helix box plot — Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7

GPCRdb(A)
GPCRdb(A)
V2 receptor
TM2
2x56 2.57x56 Q92
2x57 2.58x57 V93
TM3
3x29 3.29x29 K116
3x32 3.32x32 Q119
3x33 3.33x33 M120
3x36 3.36x36 M123
TM4
4x61 4.60x61 Q174
4x65 4.64x65 F178
TM5
5x39 5.38x39 Y205
5x40 5.39x40 V206
5x43 5.42x43 I209
TM6
6x48 6.48x48 W284
6x51 6.51x51 F287
6x52 6.52x52 F288
6x55 6.55x55 Q291
TM7
7x38 7.39x38 M311