PDB
9UVX
Resolution
3.3 Å
Released
May 6, 2026
Receptor
V2
Class
A
Species
Homo sapiens
Ligand
OPC-51803
Function
Agonist (partial)
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
OPC-51803 Q119 3.32x32 TM3 polar (hydrogen bond)
OPC-51803 Q119 3.32x32 TM3 polar (hydrogen bond)
OPC-51803 M123 3.36x36 TM3 hydrophobic
OPC-51803 M123 3.36x36 TM3 Van der Waals
OPC-51803 Q174 4.60x61 TM4 Van der Waals
OPC-51803 F178 4.64x65 TM4 Van der Waals
OPC-51803 F178 4.64x65 TM4 hydrophobic
OPC-51803 E198 ECL2 polar (charge-assisted hydrogen bond)
OPC-51803 P199 ECL2 Van der Waals
OPC-51803 P199 ECL2 hydrophobic
OPC-51803 V206 5.39x40 TM5 hydrophobic
OPC-51803 V206 5.39x40 TM5 Van der Waals
OPC-51803 I209 5.42x43 TM5 hydrophobic
OPC-51803 I209 5.42x43 TM5 Van der Waals
OPC-51803 F365 6.51x51 TM6 hydrophobic
OPC-51803 F365 6.51x51 TM6 Van der Waals
OPC-51803 Q369 6.55x55 TM6 Van der Waals
OPC-51803 A372 6.58x58 TM6 Van der Waals
OPC-51803 A372 6.58x58 TM6 hydrophobic
OPC-51803 A373 6.59x59 TM6 Van der Waals
OPC-51803 A373 6.59x59 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
Helix box plot — Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7

GPCRdb(A)
GPCRdb(A)
V2 receptor
TM3
3x32 3.32x32 Q119
3x36 3.36x36 M123
TM4
4x61 4.60x61 Q174
4x65 4.64x65 F178
TM5
5x40 5.39x40 V206
5x43 5.42x43 I209
TM6
6x51 6.51x51 F287
6x55 6.55x55 Q291
6x58 6.58x58 A294
6x59 6.59x59 A295