PDB
9UVZ
Resolution
3.0 Å
Released
May 6, 2026
Receptor
LPA2
Class
A
Species
Homo sapiens
Ligand
Ki16425
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Ki16425 Y14 N-term polar (hydrogen bond)
Ki16425 Y14 N-term Van der Waals
Ki16425 K19 N-term polar (charge-assisted hydrogen bond)
Ki16425 T89 ECL1 Van der Waals
Ki16425 T89 ECL1 polar (hydrogen bond)
Ki16425 T93 23.50x50 ECL1 polar (hydrogen bond)
Ki16425 T93 23.50x50 ECL1 Van der Waals
Ki16425 R104 3.28x28 TM3 polar (charge-assisted hydrogen bond)
Ki16425 Q105 3.29x29 TM3 Van der Waals
Ki16425 D109 3.33x33 TM3 polar (charge-assisted hydrogen bond)
Ki16425 M178 ECL2 hydrophobic
Ki16425 M178 ECL2 Van der Waals
Ki16425 A179 ECL2 Van der Waals
Ki16425 W190 5.43x43 TM5 hydrophobic
Ki16425 W190 5.43x43 TM5 Van der Waals
Ki16425 W625 6.48x48 TM6 Van der Waals
Ki16425 W625 6.48x48 TM6 hydrophobic
Ki16425 G628 6.51x51 TM6 Van der Waals
Ki16425 Q629 6.52x52 TM6 Van der Waals
Ki16425 L632 6.55x55 TM6 Van der Waals
Ki16425 L632 6.55x55 TM6 hydrophobic
Ki16425 E648 7.35x34 TM7 Van der Waals
Ki16425 K649 7.36x35 TM7 Van der Waals
Ki16425 F651 7.38x37 TM7 hydrophobic
Ki16425 F651 7.38x37 TM7 Van der Waals
Ki16425 L652 7.39x38 TM7 hydrophobic
Ki16425 L652 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R F H ICL1ECL1 T G P R T A R L ECL1ICL2 V Q L H S R L ICL2ECL2 W H C L C A L D R C S R M A P L L ECL2ICL3 E H V S ICL3ECL3 C E S C ECL3N-term M G Q C Y Y N E T I G F F Y N N S G K E L S S H W R N-termC-term C A C L R Q S T R E S V H Y T S S A Q G G A S T R I M L P E N G H P L M D S T L C-term P K D V V V V A L G L T V S V L V L L T N L L V I A A I A S N Q P I Y Y L L G N L A A A D L F A G V A Y L F L M F H S L E G W F L R Q G L L D T S L T A S V A T L L A I A V E R H R S V M A P R G R V V M L I V G V W V A A L G L G L L P A H S S R S Y L A V W A L S S L L V F L L M V A V Y T R I F F Y V R R R V Q R M A C H P R Y R E T T L S L V K T V V I I L G A F V V C W T P G Q V V L L L D G L G N V L A V E K Y F L L L A E A N S L V N A A V Y S C R D A E F R R M R R T L L C
Helix box plot — Download: PNG | SVG L N T L L V L V S V T L G L A V V V V D 1 G N L A A A D L F A G V A Y L F L M F H 2 A L L T A V S A T L S T D L L G Q R L F 3 V V M L I V G V W V A A L G L G L L P A 4 Y V A V M L L F V L L S S L A W V A L Y 5 V I I L G A F V V C W T P G Q V V L L L 6 A A N V L S N A E A L L L F Y K E V A 7

GPCRdb(A)
GPCRdb(A)
LPA2 receptor
ECL1
23x50 23.50x50 T93
TM3
3x28 3.28x28 R104
3x29 3.29x29 Q105
3x33 3.33x33 D109
TM5
5x43 5.43x43 W190
TM6
6x48 6.48x48 W251
6x51 6.51x51 G254
6x52 6.52x52 Q255
6x55 6.55x55 L258
TM7
7x34 7.35x34 E274
7x35 7.36x35 K275
7x37 7.38x37 F277
7x38 7.39x38 L278