PDB
9UYI
Resolution
3.2 Å
Released
Nov. 19, 2025
Receptor
chemerin 2
Class
A
Species
Homo sapiens
Ligand
Chemerin
Function
Agonist
Reference
10.1126/SCIENCE.ADT8794

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Ligand Amino Acid Generic Number Segment Interaction Type
Chemerin Y93 2.60x60 TM2 polar (hydrogen bond)
Chemerin Y93 2.60x60 TM2 Van der Waals
Chemerin F101 ECL1 aromatic (face-to-edge)
Chemerin F101 ECL1 Van der Waals
Chemerin S114 3.29x29 TM3 Van der Waals
Chemerin S114 3.29x29 TM3 polar (hydrogen bond)
Chemerin S114 3.29x29 TM3 polar (hydrogen bond with backbone)
Chemerin A117 3.32x32 TM3 hydrophobic
Chemerin Q118 3.33x33 TM3 polar (hydrogen bond)
Chemerin Q118 3.33x33 TM3 Van der Waals
Chemerin R176 ECL2 Van der Waals
Chemerin V179 ECL2 Van der Waals
Chemerin V179 ECL2 hydrophobic
Chemerin F181 ECL2 hydrophobic
Chemerin F181 ECL2 Van der Waals
Chemerin L186 ECL2 Van der Waals
Chemerin L186 ECL2 hydrophobic
Chemerin Y188 45.51x51 ECL2 hydrophobic
Chemerin N189 45.52x52 ECL2 Van der Waals
Chemerin N189 45.52x52 ECL2 polar (hydrogen bond)
Chemerin Q192 ECL2 polar (hydrogen bond)
Chemerin Y262 6.51x51 TM6 hydrophobic
Chemerin Y262 6.51x51 TM6 Van der Waals
Chemerin H273 6.62x62 TM6 Van der Waals
Chemerin S278 ECL3 Van der Waals
Chemerin H280 ECL3 Van der Waals
Chemerin I286 7.35x34 TM7 hydrophobic
Chemerin T290 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K K ICL1ECL1 F H W P F ECL1ICL2 P V L S H R H R ICL2ECL2 D T V E F N N H T L C Y N N F Q K H D P D ECL2ICL3 I L I ICL3ECL3 H N S Y S ECL3N-term M E D L E E T L F E E F E N Y S Y D L D Y Y S L E S D L E E K V Q L N-termC-term A E I L K Y T L W E V S C S G T V S E Q L R N S E T K N L C L L E T A Q C-term G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H T L K N S L I V I I F I W L L A S L I G G P A L Y F R L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F R S F Q A R S V
Helix box plot — Download: PNG | SVG A N G P I G L V F A L C Y L V L S V W H 1 L N L A I A D F I F L L F L P L Y I S Y 2 V T L F F V S A F M N L Q A T F S N A K 3 S L I V I I F I W L L A S L I G G P A L 4 Y C I S M T L L P F L Y G I I F K V W T L 5 L V V V V A F V V C W T P Y H L F S I W 6 I P N L C S N L F A L G T S L P I G A 7

GPCRdb(A)
GPCRdb(A)
chemerin receptor 2
TM2
2x60 2.60x60 Y93
TM3
3x29 3.29x29 S114
3x32 3.32x32 A117
3x33 3.33x33 Q118
ECL2
45x51 45.51x51 Y188
45x52 45.52x52 N189
TM6
6x51 6.51x51 Y262
6x62 6.62x62 H273
TM7
7x34 7.35x34 I286
7x38 7.39x38 T290