PDB
9UYJ
Resolution
3.3 Å
Released
Nov. 19, 2025
Receptor
chemerin 2
Class
A
Species
Homo sapiens
Ligand
Chemerin
Function
Agonist
Reference
10.1126/SCIENCE.ADT8794

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Ligand Amino Acid Generic Number Segment Interaction Type
Chemerin Y93 2.60x60 TM2 aromatic (face-to-edge)
Chemerin Y93 2.60x60 TM2 polar (hydrogen bond)
Chemerin Y93 2.60x60 TM2 Van der Waals
Chemerin S114 3.29x29 TM3 Van der Waals
Chemerin A117 3.32x32 TM3 hydrophobic
Chemerin A117 3.32x32 TM3 Van der Waals
Chemerin Q118 3.33x33 TM3 Van der Waals
Chemerin M121 3.36x36 TM3 Van der Waals
Chemerin L186 ECL2 hydrophobic
Chemerin L186 ECL2 Van der Waals
Chemerin C187 45.50x50 ECL2 Van der Waals
Chemerin Y188 45.51x51 ECL2 Van der Waals
Chemerin Y188 45.51x51 ECL2 hydrophobic
Chemerin N189 45.52x52 ECL2 Van der Waals
Chemerin N189 45.52x52 ECL2 polar (hydrogen bond)
Chemerin F191 ECL2 Van der Waals
Chemerin Q192 ECL2 Van der Waals
Chemerin K210 5.42x43 TM5 polar (charge-assisted hydrogen bond)
Chemerin Y262 6.51x51 TM6 Van der Waals
Chemerin Y262 6.51x51 TM6 polar (hydrogen bond)
Chemerin E269 6.58x58 TM6 Van der Waals
Chemerin Y277 ECL3 polar (hydrogen bond)
Chemerin H280 ECL3 Van der Waals
Chemerin Q283 ECL3 Van der Waals
Chemerin I286 7.35x34 TM7 hydrophobic
Chemerin I286 7.35x34 TM7 Van der Waals
Chemerin T290 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K K ICL1ECL1 F H W P F ECL1ICL2 P V L S H R H R ICL2ECL2 D T V E F N N H T L C Y N N F Q K H D P D ECL2ICL3 I L I ICL3ECL3 H N S Y S ECL3N-term M E D L E E T L F E E F E N Y S Y D L D Y Y S L E S D L E E K V Q L N-termC-term A E I L K Y T L W E V S C S G T V S E Q L R N S E T K N L C L L E T A Q C-term G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H T L K N S L I V I I F I W L L A S L I G G P A L Y F R L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F R S F Q A R S V
Helix box plot — Download: PNG | SVG A N G P I G L V F A L C Y L V L S V W H 1 L N L A I A D F I F L L F L P L Y I S Y 2 V T L F F V S A F M N L Q A T F S N A K 3 S L I V I I F I W L L A S L I G G P A L 4 Y C I S M T L L P F L Y G I I F K V W T L 5 L V V V V A F V V C W T P Y H L F S I W 6 I P N L C S N L F A L G T S L P I G A 7

GPCRdb(A)
GPCRdb(A)
chemerin receptor 2
TM2
2x60 2.60x60 Y93
TM3
3x29 3.29x29 S114
3x32 3.32x32 A117
3x33 3.33x33 Q118
3x36 3.36x36 M121
ECL2
45x50 45.50x50 C187
45x51 45.51x51 Y188
45x52 45.52x52 N189
TM5
5x43 5.42x43 K210
TM6
6x51 6.51x51 Y262
6x58 6.58x58 E269
TM7
7x34 7.35x34 I286
7x38 7.39x38 T290