PDB
9V1H
Resolution
2.9 Å
Released
Feb. 4, 2026
Receptor
NPFF2
Class
A
Species
Homo sapiens
Ligand
GUB08248
Function
Agonist
Reference
10.1038/S41401-025-01741-1

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Ligand Amino Acid Generic Number Segment Interaction Type
GUB08248 D105 2.64x63 TM2 polar (charge-assisted hydrogen bond)
GUB08248 D105 2.64x63 TM2 polar (hydrogen bond with backbone)
GUB08248 Q125 3.32x32 TM3 Van der Waals
GUB08248 Q125 3.32x32 TM3 polar (hydrogen bond)
GUB08248 V129 3.36x36 TM3 hydrophobic
GUB08248 V129 3.36x36 TM3 Van der Waals
GUB08248 M175 4.57x57 TM4 hydrophobic
GUB08248 M175 4.57x57 TM4 Van der Waals
GUB08248 W205 ECL2 Van der Waals
GUB08248 W205 ECL2 hydrophobic
GUB08248 R207 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
GUB08248 E208 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
GUB08248 R216 5.35x36 TM5 polar (charge-assisted hydrogen bond)
GUB08248 Y219 5.38x39 TM5 hydrophobic
GUB08248 T220 5.39x40 TM5 polar (hydrogen bond)
GUB08248 L223 5.42x43 TM5 hydrophobic
GUB08248 L223 5.42x43 TM5 Van der Waals
GUB08248 W291 6.52x52 TM6 Van der Waals
GUB08248 W291 6.52x52 TM6 aromatic (face-to-edge)
GUB08248 L307 ECL3 Van der Waals
GUB08248 N311 7.31x30 TM7 polar (hydrogen bond)
GUB08248 N311 7.31x30 TM7 Van der Waals
GUB08248 H319 7.39x38 TM7 polar (hydrogen bond)
GUB08248 H319 7.39x38 TM7 Van der Waals
GUB08248 F323 7.43x42 TM7 Van der Waals
GUB08248 F323 7.43x42 TM7 hydrophobic

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ICL1 K H M H ICL1ECL1 G W P F ECL1ICL2 P F K P K L ICL2ECL2 H V Q E E K Y Y R V R L N S Q N K T S P V Y W C R E D W P N Q ECL2ICL3 G R K N Q E Q W ICL3ECL3 D L S P N E L ECL3N-term M N S F F G T P A A S W C L L E S D V S S A P D K E A G R E R R A L S V Q Q R G G P A W S G S L E W S R Q S A G D R R R L G L S R Q T A K S S W S R S R D R T C C C R R A W W I L V P A A D R A R R E R F I M N E K W D T N S S E N W H P I W N V N D T K H H L Y S D I N I T Y V N Y Y L H Q P Q V N-termC-term Q K R A K P M E A Y A L K A K S H V L I N T S N Q L V Q E S T F Q N P H G E T L L Y R K S A E K P Q Q E L V M E E L K E T T N S S E I C-term A A I F I I S Y F L I F F L C M M G N T V V C F I V M R N T V T N L F I L N L A I S D L L V G I F C M P I T L L D N I I A G N T M C K I S G L V Q G I S V A A S V F T L V A I A V D R F Q C V V Y T I K T A F V I I M I I W V L A I T I M S P S A V M L E M R K I Y T T V L F A N I Y L A P L S L I V I M Y G R I G I S L F R A A V P H T H V V S R K K Q K I I K M L L I V A L L F I L S W L P L W T L M M L S D Y A Q I I N I Y I Y P F A H W L A F G N S S V N P I I Y G F F N E N F Q E Q L C F R R G A F Q L
Helix box plot — Download: PNG | SVG T N G M M C L F F I L F Y S I I F I A A 1 L N L A I S D L L V G F I C M P I T L L D 2 A V L T F V S A A V S I G Q V L G S I K 3 A F V I I M I I W V L A I T I M S P S 4 Y M I V I L S L P A L Y I N A F L V T T Y 5 L I V A L L F I L S W L P L W T L M M L 6 I P N V S S N G F A L W H A F P Y I Y 7

GPCRdb(A)
GPCRdb(A)
NPFF2 receptor
TM2
2x63 2.64x63 D207
TM3
3x32 3.32x32 Q227
3x36 3.36x36 V231
TM4
4x57 4.57x57 M277
ECL2
45x51 45.51x51 R309
45x52 45.52x52 E310
TM5
5x36 5.35x36 R318
5x39 5.38x39 Y321
5x40 5.39x40 T322
5x43 5.42x43 L325
TM6
6x52 6.52x52 W393
TM7
7x30 7.31x30 N413
7x38 7.39x38 H421
7x42 7.43x42 F425