PDB
9VB1
Resolution
3.3 Å
Released
June 3, 2026
Receptor
NTS1
Class
A
Species
Homo sapiens
Ligand
JMV449
Function
Agonist
Reference
10.1038/S41586-026-10228-W

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Ligand Amino Acid Generic Number Segment Interaction Type
JMV449 H143 ECL1 polar (hydrogen bond with backbone)
JMV449 H143 ECL1 Van der Waals
JMV449 Y157 3.29x29 TM3 Van der Waals
JMV449 Y157 3.29x29 TM3 polar (hydrogen bond)
JMV449 R224 ECL2 Van der Waals
JMV449 V235 ECL2 hydrophobic
JMV449 V235 ECL2 Van der Waals
JMV449 C236 45.50x50 ECL2 Van der Waals
JMV449 P238 45.52x52 ECL2 Van der Waals
JMV449 R335 6.55x55 TM6 Van der Waals
JMV449 F338 6.58x58 TM6 Van der Waals
JMV449 F338 6.58x58 TM6 hydrophobic
JMV449 D343 ECL3 Van der Waals
JMV449 W346 ECL3 hydrophobic
JMV449 W346 ECL3 Van der Waals
JMV449 T347 7.24x23 TM7 Van der Waals
JMV449 Y351 7.28x27 TM7 hydrophobic
JMV449 Y351 7.28x27 TM7 Van der Waals
JMV449 Y358 7.35x34 TM7 hydrophobic
JMV449 Y358 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
Helix box plot — Download: PNG | SVG T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM3
3x29 3.29x29 Y145
ECL2
45x50 45.50x50 C224
45x52 45.52x52 P226
TM6
6x55 6.55x55 R323
6x58 6.58x58 F326
TM7
7x23 7.24x23 T335
7x27 7.28x27 Y339
7x34 7.35x34 Y346