PDB
9VB5
Resolution
3.1 Å
Released
June 3, 2026
Receptor
NTS1
Class
A
Species
Homo sapiens
Ligand
JMV449
Function
Agonist
Reference
10.1038/S41586-026-10228-W

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Ligand Amino Acid Generic Number Segment Interaction Type
JMV449 F127 2.65x64 TM2 hydrophobic
JMV449 Y145 3.29x29 TM3 hydrophobic
JMV449 C224 45.50x50 ECL2 Van der Waals
JMV449 C224 45.50x50 ECL2 polar (hydrogen bond with backbone)
JMV449 T225 45.51x51 ECL2 Van der Waals
JMV449 T225 45.51x51 ECL2 polar (hydrogen bond)
JMV449 T230 5.32x33 TM5 polar (hydrogen bond)
JMV449 T230 5.32x33 TM5 Van der Waals
JMV449 I237 5.39x40 TM5 hydrophobic
JMV449 W334 ECL3 Van der Waals
JMV449 W334 ECL3 hydrophobic
JMV449 Y339 7.28x27 TM7 Van der Waals
JMV449 Y339 7.28x27 TM7 polar (hydrogen bond with backbone)
JMV449 Y342 7.31x30 TM7 polar (hydrogen bond)
JMV449 Y342 7.31x30 TM7 polar (hydrogen bond)
JMV449 H343 7.32x31 TM7 Van der Waals
JMV449 Y346 7.35x34 TM7 Van der Waals
JMV449 Y346 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
Helix box plot — Download: PNG | SVG T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
ECL2
45x50 45.50x50 C224
45x51 45.51x51 T225
TM5
5x33 5.32x33 T230
5x40 5.39x40 I237
TM7
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x31 7.32x31 H343
7x34 7.35x34 Y346