PDB
9VJ6
Resolution
2.6 Å
Released
Nov. 12, 2025
Receptor
5-HT1A
Class
A
Species
Homo sapiens
Ligand
NLX-101
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
NLX-101 M92 2.60x59 TM2 hydrophobic
NLX-101 A93 2.61x60 TM2 hydrophobic
NLX-101 Y96 2.64x63 TM2 hydrophobic
NLX-101 W102 23.50x50 ECL1 hydrophobic
NLX-101 F112 3.28x28 TM3 hydrophobic
NLX-101 I113 3.29x29 TM3 hydrophobic
NLX-101 D116 3.32x32 TM3 polar (charge-assisted hydrogen bond)
NLX-101 V117 3.33x33 TM3 hydrophobic
NLX-101 V117 3.33x33 TM3 Van der Waals
NLX-101 C120 3.36x36 TM3 hydrophobic
NLX-101 C120 3.36x36 TM3 Van der Waals
NLX-101 T121 3.37x37 TM3 Van der Waals
NLX-101 C187 45.50x50 ECL2 Van der Waals
NLX-101 I189 45.52x52 ECL2 hydrophobic
NLX-101 I189 45.52x52 ECL2 Van der Waals
NLX-101 S199 5.42x43 TM5 Van der Waals
NLX-101 A203 5.46x461 TM5 Van der Waals
NLX-101 A203 5.46x461 TM5 hydrophobic
NLX-101 W358 6.48x48 TM6 Van der Waals
NLX-101 F361 6.51x51 TM6 hydrophobic
NLX-101 F361 6.51x51 TM6 Van der Waals
NLX-101 F362 6.52x52 TM6 Van der Waals
NLX-101 F362 6.52x52 TM6 hydrophobic
NLX-101 N386 7.39x38 TM7 Van der Waals
NLX-101 Y390 7.43x42 TM7 Van der Waals
NLX-101 Y390 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R S L Q ICL1ECL1 K W T L ECL1ICL2 P I D Y V N K R ICL2ECL2 R T P E D R S D P D A C T I S K ECL2ICL3 E K T G A D T R H G A S P A P Q P K K S V N G E S G S R N W R L G V E S K A G G A L C A N G A V R Q G D D G A A L E V I E V H R V G N S K E H L P L P S E A G P T P C A P A S F E R ICL3ECL3 E S S C H M ECL3N-term M D V L S P G Q G N N T T S P P A P F E T G G N T T G I S D V N-termC-term K C K F C R Q C-term T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N G Q V T C D L F I A L D V L C C T S S I L H L C A I A L D R Y W A I T D T P R R A A A L I S L T W L I G F L I S I P P M L G W D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F K K F Q N A I I
Helix box plot — Download: PNG | SVG A N G L V A C F I L T G L L L S T I V Q 1 G S L A V T D L M V S L V V L P M A A L Y 2 A C L H L I S S T C C L V D L A I F L D 3 A A A L I S L T W L I G F L I S I P P M 4 Y L V L M L L L P I Y F A G F T S Y I T Y 5 G I I M G T F I L C W L P F F I V A L V 6 V P N L L S N S Y G L W N I I A G L L 7

GPCRdb(A)
GPCRdb(A)
5-HT1A receptor
TM2
2x59 2.60x59 M92
2x60 2.61x60 A93
2x63 2.64x63 Y96
ECL1
23x50 23.50x50 W102
TM3
3x28 3.28x28 F112
3x29 3.29x29 I113
3x32 3.32x32 D116
3x33 3.33x33 V117
3x36 3.36x36 C120
3x37 3.37x37 T121
ECL2
45x50 45.50x50 C187
45x52 45.52x52 I189
TM5
5x43 5.42x43 S199
5x461 5.46x461 A203
TM6
6x48 6.48x48 W358
6x51 6.51x51 F361
6x52 6.52x52 F362
TM7
7x38 7.39x38 N386
7x42 7.43x42 Y390