PDB
9VO0
Resolution
2.8 Å
Released
Jan. 28, 2026
Receptor
S1P1
Class
A
Species
Homo sapiens
Ligand
Ponesimod
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Ponesimod F125 3.33x33 TM3 hydrophobic
Ponesimod L128 3.36x36 TM3 hydrophobic
Ponesimod V132 3.40x40 TM3 hydrophobic
Ponesimod C206 5.43x43 TM5 hydrophobic
Ponesimod F210 5.47x47 TM5 aromatic (edge-to-face)
Ponesimod W269 6.48x48 TM6 hydrophobic
Ponesimod L272 6.51x51 TM6 hydrophobic
Ponesimod L276 6.55x55 TM6 hydrophobic
Ponesimod L297 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
Helix box plot — Download: PNG | SVG I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7

GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM3
3x33 3.33x33 F125
3x36 3.36x36 L128
3x40 3.40x40 V132
TM5
5x43 5.43x43 C206
5x47 5.47x47 F210
TM6
6x48 6.48x48 W269
6x51 6.51x51 L272
6x55 6.55x55 L276
TM7
7x38 7.39x38 L297