PDB
9W0Q
Resolution
3.2 Å
Released
April 22, 2026
Receptor
TAS2R14
Class
T2
Species
Homo sapiens
Ligand
Function
TANGERETIN
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
TANGERETIN I62 2.57x57 TM2 Van der Waals
TANGERETIN F82 3.25x25 TM3 aromatic (edge-to-face)
TANGERETIN F82 3.25x25 TM3 hydrophobic
TANGERETIN W89 3.32x32 TM3 aromatic (edge-to-face)
TANGERETIN F172 ECL2 Van der Waals
TANGERETIN F175 5.35x36 TM5 Van der Waals
TANGERETIN S176 5.36x37 TM5 Van der Waals
TANGERETIN V180 5.40x41 TM5 Van der Waals
TANGERETIN S183 5.43x44 TM5 Van der Waals
TANGERETIN I262 7.35x34 TM7 Van der Waals
TANGERETIN S265 7.38x37 TM7 Van der Waals
TANGERETIN Q266 7.39x38 TM7 polar (hydrogen bond)
TANGERETIN G269 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
Helix box plot — Download: PNG | SVG S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7

GPCRdb(A)
GPCRdb(A)
TAS2R14
TM2
2x57 2.57x57 I62
TM3
3x25 3.25x25 F82
3x32 3.32x32 W89
TM5
5x41 5.40x41 V180
5x44 5.43x44 S183
TM7
7x34 7.35x34 I262
7x37 7.38x37 S265
7x38 7.39x38 Q266
7x41 7.42x41 G269