PDB
9W0W
Resolution
3.2 Å
Released
April 22, 2026
Receptor
TAS2R46
Class
T2
Species
Homo sapiens
Ligand
strychnine
Function
Agonist
Reference
10.1038/S41594-026-01786-8

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Ligand Amino Acid Generic Number Segment Interaction Type
strychnine L62 2.57x57 TM2 hydrophobic
strychnine Y85 3.29x29 TM3 hydrophobic
strychnine W88 3.32x32 TM3 hydrophobic
strychnine F261 7.35x34 TM7 hydrophobic
strychnine E265 7.39x38 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 K I ICL1ECL1 P A F N ECL1ICL2 N F S N L I F L H L K R ICL2ECL2 I W T K E Y E G N M T W K I K L R S A M Y L S ECL2ICL3 K G S Q ICL3ECL3 L E N ECL3N-term M N-termC-term K G E K P S S S C-term I T F L P I I F S I L I V V T F V I G N F A N G F I A L V N S I E W F K R Q S F A D Q I L T A L A V S R V G L L W V L V L N W Y A T E L N S I E V R I T A Y N V W A V I N H F S N W L A T S L S I F Y L L K I A R V K S V V L V I L L G P L L F L V C H L F V I N M N Q I N T T V T I L A N L V P F T L T L I S F L L L I C S L C K H L K K M Q L H G D P S M K V H I K A L Q T V T S F L L L C A I Y F L S I I M S V W S F E S K P V F M F C E A I A F S Y P S T H P F I L I W G N K K F L S V R Y L K Q T V L W H W V
Helix box plot — Download: PNG | SVG G N A F N G I V F T V V I L I S F I I P 1 T A L A V S R V G L L W V L V L N W Y A 2 S T A L W N S F H N I V A W V N Y A T I 3 V L V I L L G P L L F L V C H L F V I N 4 F S I L T L T F P V L N A L I T V T T N 5 V T S F L L L C A I Y F L S I I M S V W 6 F P H T S P Y S F A I A E C F M F V P 7

GPCRdb(A)
GPCRdb(A)
TAS2R46
TM2
2x57 2.57x57 L62
TM3
3x29 3.29x29 Y85
3x32 3.32x32 W88
TM7
7x34 7.35x34 F261
7x38 7.39x38 E265