PDB
9W33
Resolution
2.7 Å
Released
Jan. 21, 2026
Receptor
SST5
Class
A
Species
Homo sapiens
Ligand
S5A1
Function
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
S5A1 R39 1.31x31 TM1 polar (charge-assisted hydrogen bond)
S5A1 Y47 1.39x39 TM1 polar (hydrogen bond)
S5A1 L96 2.60x60 TM2 Van der Waals
S5A1 L96 2.60x60 TM2 hydrophobic
S5A1 Q99 2.63x63 TM2 Van der Waals
S5A1 Q99 2.63x63 TM2 polar (hydrogen bond)
S5A1 N100 2.64x64 TM2 Van der Waals
S5A1 N100 2.64x64 TM2 polar (hydrogen bond)
S5A1 M116 3.29x29 TM3 polar (hydrogen bond)
S5A1 D119 3.32x32 TM3 Van der Waals
S5A1 G120 3.33x33 TM3 Van der Waals
S5A1 Q123 3.36x36 TM3 Van der Waals
S5A1 L174 4.60x61 TM4 Van der Waals
S5A1 L174 4.60x61 TM4 hydrophobic
S5A1 C186 45.50x50 ECL2 Van der Waals
S5A1 N187 45.51x51 ECL2 Van der Waals
S5A1 A188 45.52x52 ECL2 Van der Waals
S5A1 A188 45.52x52 ECL2 polar (hydrogen bond with backbone)
S5A1 S189 ECL2 Van der Waals
S5A1 W190 ECL2 Van der Waals
S5A1 W190 ECL2 hydrophobic
S5A1 V194 ECL2 Van der Waals
S5A1 F201 5.38x39 TM5 aromatic (edge-to-face)
S5A1 F201 5.38x39 TM5 Van der Waals
S5A1 I202 5.39x40 TM5 hydrophobic
S5A1 I202 5.39x40 TM5 Van der Waals
S5A1 W261 6.48x48 TM6 Van der Waals
S5A1 W261 6.48x48 TM6 hydrophobic
S5A1 F264 6.51x51 TM6 aromatic (edge-to-face)
S5A1 F264 6.51x51 TM6 Van der Waals
S5A1 F265 6.52x52 TM6 hydrophobic
S5A1 F265 6.52x52 TM6 Van der Waals
S5A1 N268 6.55x55 TM6 Van der Waals

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ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
Helix box plot — Download: PNG | SVG T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7

GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM1
1x31 1.31x31 R39
1x39 1.39x39 Y47
TM2
2x60 2.60x60 L96
2x63 2.63x63 Q99
2x64 2.64x64 N100
TM3
3x29 3.29x29 M116
3x32 3.32x32 D119
3x33 3.33x33 G120
3x36 3.36x36 Q123
TM4
4x61 4.60x61 L174
ECL2
45x50 45.50x50 C186
45x51 45.51x51 N187
45x52 45.52x52 A188
TM5
5x39 5.38x39 F201
5x40 5.39x40 I202
TM6
6x48 6.48x48 W261
6x51 6.51x51 F264
6x52 6.52x52 F265
6x55 6.55x55 N268