PDB
9W3F
Resolution
3.0 Å
Released
June 10, 2026
Receptor
β2
Class
A
Species
Homo sapiens
Ligand
BERBERINE
Function
Antagonist
Reference
10.1038/S41421-026-00892-7

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Ligand Amino Acid Generic Number Segment Interaction Type
BERBERINE V114 3.33x33 TM3 hydrophobic
BERBERINE F193 45.52x52 ECL2 aromatic (edge-to-face)
BERBERINE F289 6.51x51 TM6 aromatic (edge-to-face)
BERBERINE F290 6.52x52 TM6 hydrophobic
BERBERINE Y308 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
Helix box plot — Download: PNG | SVG V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7

GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x33 3.33x33 V114
ECL2
45x52 45.52x52 F193
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
TM7
7x34 7.35x34 Y308