PDB
9WG4
Resolution
3.3 Å
Released
June 17, 2026
Receptor
OR52E8
Class
O1
Species
Homo sapiens
Ligand
(3R)-3-Hydroxy-3-methylhexanoic acid
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
(3R)-3-Hydroxy-3-methylhexanoic acid H183 45.52x52 ECL2 polar (hydrogen bond)
(3R)-3-Hydroxy-3-methylhexanoic acid G201 5.39x39 TM5 Van der Waals
(3R)-3-Hydroxy-3-methylhexanoic acid N204 5.42x42 TM5 polar (hydrogen bond)
(3R)-3-Hydroxy-3-methylhexanoic acid N204 5.42x42 TM5 polar (hydrogen bond)
(3R)-3-Hydroxy-3-methylhexanoic acid F261 6.55x55 TM6 Van der Waals
(3R)-3-Hydroxy-3-methylhexanoic acid F261 6.55x55 TM6 hydrophobic
(3R)-3-Hydroxy-3-methylhexanoic acid R265 6.59x59 TM6 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 Q S L H ICL1ECL1 T K E I ECL1ICL2 P L R Y T M I L ICL2ECL2 L P F C G H R I I P H T Y C E H M G I A R L A C A S ECL2ICL3 L P ICL3ECL3 H N I ECL3N-term M S T S N H T Q F H P S S F L L L G I P G N-termC-term T N H C-term L E D V H I W I G V P F F F V Y L V A L L G N T A L L F V I Q T E E P M Y Y F L A M L D S I D L G L S T A T I P K M L G I F W F N S F G G C L S H M F F I H F F T A M E S I V L V A M A F D R Y I A I C K T S K I I S L I A G I A V L R S L Y M V V P L V F L L L R I K V N I R F G L G N I S L L L L D V I L I I L S Y V R I L Y A V F C S W E A R L K A L N T C G S H I G V I L A F F T P A F F S F L T H R F G P Q Y I H I I L A N L Y V V V P P A L N P V I Y G V R T K Q V L R I R E R I F L K
Helix box plot — Download: PNG | SVG T N G L L A V L Y V F F F P V G I W I H 1 A M L D S I D L G L S T A T I P K M L G 2 A V L V I S E M A T F F H I F F M H S L 3 I S L I A G I A V L R S L Y M V V P L V 4 Y S L I I L I V D L L L L S I N G L G F 5 G S H I G V I L A F F T P A F F S F L T 6 V P N L A P P V V V Y L N A L I I H I 7

GPCRdb(A)
GPCRdb(A)
OR52E8
ECL2
45x52 45.52x52 H183
TM5
5x39 5.39x39 F200
5x42 5.42x42 G203
TM6
6x55 6.55x55 F260
6x59 6.59x59 R264