PDB
9WIJ
Resolution
3.1 Å
Released
July 1, 2026
Receptor
GPR84
Class
A
Species
Homo sapiens
Ligand
GLPG1205
Function
NAM
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
GLPG1205 Y69 2.53x53 TM2 hydrophobic
GLPG1205 L100 3.32x32 TM3 hydrophobic
GLPG1205 F101 3.33x33 TM3 aromatic (edge-to-face)
GLPG1205 N104 3.36x36 TM3 polar (hydrogen bond)
GLPG1205 N104 3.36x36 TM3 Van der Waals
GLPG1205 T167 ECL2 Van der Waals
GLPG1205 S169 45.51x51 ECL2 Van der Waals
GLPG1205 F170 45.52x52 ECL2 Van der Waals
GLPG1205 F170 45.52x52 ECL2 hydrophobic
GLPG1205 Y332 6.48x48 TM6 polar (hydrogen bond)
GLPG1205 Y332 6.48x48 TM6 Van der Waals
GLPG1205 F335 6.51x51 TM6 aromatic (edge-to-face)
GLPG1205 F335 6.51x51 TM6 Van der Waals
GLPG1205 T359 7.42x41 TM7 Van der Waals
GLPG1205 W360 7.43x42 TM7 polar (hydrogen bond)
GLPG1205 W360 7.43x42 TM7 Van der Waals
GLPG1205 N362 7.45x45 TM7 Van der Waals
GLPG1205 G363 7.46x46 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P K L R ICL1ECL1 L H W R T ECL1ICL2 P K L F P Q V F ICL2ECL2 I L V P V V C T C S F D R I R ECL2ICL3 L R Q A S I H S N H V A R T D E A M P G R F Q E L D S R L A S G G P S E G I S S E P V S A A T T Q T L E G D S S E V G D Q I N S K R A K Q M A E K S P P E A S A K A Q P I K G A R R A ICL3ECL3 R V Q A P R ECL3N-term M W N S S D A N F S C Y H E S V L N-termC-term G P R S F H R L H C-term G Y R Y V A V S W G V V V A V T G T V G N V L T L L A L A I Q T R F N L L I A N L T L A D L L Y C T L L Q P F S V D T Y L H G A T F C R V F G L L L F A S N S V S I L T L C L I A L G R Y L L I A H S A K G I V L A L V S T W V V G V A S F A P L W P I Y G R P Y T T I L M G I Y F V L G L S S V G I F Y C L I H R Q V K R A A Q A L D Q Y K P D S S S E F G K V T R M C F A V F L C F A L S Y I P F L L L N I L D A V V H M L A A N L T W L N G C I N P V L Y A A M N R Q Y G S F R Q A I L K R
Helix box plot — Download: PNG | SVG V N G V T G T V A V V V G W S V A V Y R 1 A N L T L A D L L Y C L T L Q P F S V D T 2 L C L T L I S V S N S A F L L L G F V R 3 I V L A L V S T W V V G V A S F A P L 4 Y F I G V S S L G L V F Y I G M L I T T Y 5 F A V F L C F A L S Y I P F L L L N I L 6 V P N I C G N L W T L N A A L M H V V 7

GPCRdb(A)
GPCRdb(A)
GPR84
TM2
2x53 2.53x53 Y69
TM3
3x32 3.32x32 L100
3x33 3.33x33 F101
3x36 3.36x36 N104
ECL2
45x51 45.51x51 S169
45x52 45.52x52 F170
TM6
6x48 6.48x48 Y332
6x51 6.51x51 F335
TM7
7x41 7.42x41 T359
7x42 7.43x42 W360
7x45 7.45x45 N362
7x46 7.46x46 G363