PDB
9WIK
Resolution
3.3 Å
Released
July 1, 2026
Receptor
GPR84
Class
A
Species
Homo sapiens
Ligand
Function
DL-175
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
DL-175 Y69 2.53x53 TM2 Van der Waals
DL-175 L100 3.32x32 TM3 hydrophobic
DL-175 F101 3.33x33 TM3 hydrophobic
DL-175 N104 3.36x36 TM3 Van der Waals
DL-175 S105 3.37x37 TM3 Van der Waals
DL-175 I108 3.40x40 TM3 Van der Waals
DL-175 F152 4.57x57 TM4 hydrophobic
DL-175 V165 ECL2 Van der Waals
DL-175 T167 ECL2 Van der Waals
DL-175 S169 45.51x51 ECL2 Van der Waals
DL-175 M183 5.43x44 TM5 halogen contact
DL-175 M183 5.43x44 TM5 hydrophobic
DL-175 Y186 5.46x461 TM5 hydrophobic
DL-175 F187 5.47x47 TM5 hydrophobic
DL-175 Y332 6.48x48 TM6 Van der Waals
DL-175 F335 6.51x51 TM6 hydrophobic
DL-175 L336 6.52x52 TM6 hydrophobic
DL-175 A356 7.39x38 TM7 Van der Waals
DL-175 T359 7.42x41 TM7 hydrophobic
DL-175 W360 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P K L R ICL1ECL1 L H W R T ECL1ICL2 P K L F P Q V F ICL2ECL2 I L V P V V C T C S F D R I R ECL2ICL3 L R Q A S I H S N H V A R T D E A M P G R F Q E L D S R L A S G G P S E G I S S E P V S A A T T Q T L E G D S S E V G D Q I N S K R A K Q M A E K S P P E A S A K A Q P I K G A R R A ICL3ECL3 R V Q A P R ECL3N-term M W N S S D A N F S C Y H E S V L N-termC-term G P R S F H R L H C-term G Y R Y V A V S W G V V V A V T G T V G N V L T L L A L A I Q T R F N L L I A N L T L A D L L Y C T L L Q P F S V D T Y L H G A T F C R V F G L L L F A S N S V S I L T L C L I A L G R Y L L I A H S A K G I V L A L V S T W V V G V A S F A P L W P I Y G R P Y T T I L M G I Y F V L G L S S V G I F Y C L I H R Q V K R A A Q A L D Q Y K P D S S S E F G K V T R M C F A V F L C F A L S Y I P F L L L N I L D A V V H M L A A N L T W L N G C I N P V L Y A A M N R Q Y G S F R Q A I L K R
Helix box plot — Download: PNG | SVG V N G V T G T V A V V V G W S V A V Y R 1 A N L T L A D L L Y C L T L Q P F S V D T 2 L C L T L I S V S N S A F L L L G F V R 3 I V L A L V S T W V V G V A S F A P L 4 Y F I G V S S L G L V F Y I G M L I T T Y 5 F A V F L C F A L S Y I P F L L L N I L 6 V P N I C G N L W T L N A A L M H V V 7

GPCRdb(A)
GPCRdb(A)
GPR84
TM2
2x53 2.53x53 Y69
TM3
3x32 3.32x32 L100
3x33 3.33x33 F101
3x36 3.36x36 N104
3x37 3.37x37 S105
3x40 3.40x40 I108
TM4
4x57 4.57x57 F152
ECL2
45x51 45.51x51 S169
TM5
5x44 5.43x44 M183
5x461 5.46x461 Y186
5x47 5.47x47 F187
TM6
6x48 6.48x48 Y332
6x51 6.51x51 F335
6x52 6.52x52 L336
TM7
7x38 7.39x38 A356
7x41 7.42x41 T359
7x42 7.43x42 W360