PDB
9WXM
Resolution
3.3 Å
Released
Nov. 19, 2025
Receptor
GPR15
Class
A
Species
Homo sapiens
Ligand
GPR15LG
Function
Agonist
Reference
10.1016/J.ISCI.2025.113935

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Ligand Amino Acid Generic Number Segment Interaction Type
GPR15LG W89 2.60x60 TM2 hydrophobic
GPR15LG M117 3.36x36 TM3 hydrophobic
GPR15LG Y182 ECL2 hydrophobic
GPR15LG A184 45.51x51 ECL2 hydrophobic
GPR15LG E185 45.52x52 ECL2 polar (hydrogen bond with backbone)
GPR15LG E185 45.52x52 ECL2 Van der Waals
GPR15LG K186 ECL2 Van der Waals
GPR15LG K187 ECL2 Van der Waals
GPR15LG K192 5.35x36 TM5 polar (charge-assisted hydrogen bond)
GPR15LG S196 5.39x40 TM5 polar (hydrogen bond)
GPR15LG F257 6.51x51 TM6 Van der Waals
GPR15LG F257 6.51x51 TM6 hydrophobic
GPR15LG K261 6.55x55 TM6 polar (charge-assisted hydrogen bond)
GPR15LG I265 6.59x59 TM6 hydrophobic
GPR15LG I265 6.59x59 TM6 Van der Waals
GPR15LG Q281 7.32x31 TM7 Van der Waals
GPR15LG Q281 7.32x31 TM7 polar (hydrogen bond)
GPR15LG F292 7.43x42 TM7 hydrophobic

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ICL1 P G S R ICL1ECL1 G L W R T ECL1ICL2 P V V S R K F R ICL2ECL2 E L T L I D D K P Y C A E K K A ECL2ICL3 Y Q Q S G K H N K ICL3ECL3 G L R Q E ECL3N-term M D P E E T S V Y L D Y Y Y A T S P N S D I R E T N-termC-term K N Y D F G S S T E T S D S H L T K A L S T F I H A E D F A R R R K R S V S L C-term H S H V P Y T S V F L P V F Y T A V F L T G V L G N L V L M G A L H F K R L I D I F I I N L A A S D F I F L V T L P L W V D K E A S L G S F L C K G S S Y M I S V N M H C S V L L L T C M S V D R Y L A I V W R T D C A Y V V C A S I W F I S C L L G L P T L L S R T P I K L I W S L V A L I F T F F V P L L S I V T C Y C C I A R K L C A H K L K K S I K I I F I V V A A F L V S W L P F N T F K F L A I V S H Y L P S A I L Q L G M E V S G P L A F A N S C V N P F I Y Y I F D S Y I V H C L I R R A C L C P
Helix box plot — Download: PNG | SVG L N G L V G T L F V A T Y F V P L F V S 1 I N L A A S D F I F L V T L P L W V D K 2 C T L L L V S C H M N V S I M Y S S G K 3 A Y V V C A S I W F I S C L L G L P T L 4 Y C T V I S L L P V F F T F I L A V L S W 5 F I V V A A F L V S W L P F N T F K F L 6 F P N V C S N A F A L P G S V E M G L 7

GPCRdb(A)
GPCRdb(A)
GPR15
TM2
2x60 2.60x60 W89
TM3
3x36 3.36x36 M117
ECL2
45x51 45.51x51 A184
45x52 45.52x52 E185
TM5
5x36 5.35x36 K192
5x40 5.39x40 S196
TM6
6x51 6.51x51 F257
6x55 6.55x55 K261
6x59 6.59x59 I265
TM7
7x31 7.32x31 Q281
7x42 7.43x42 F292