PDB
9WXM
Resolution
3.3 Å
Released
Nov. 19, 2025
Receptor
GPR15
Class
A
Species
Homo sapiens
Ligand
Function
GPR15LG
Agonist
Reference
10.1016/J.ISCI.2025.113935

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Ligand Amino Acid Generic Number Segment Interaction Type
GPR15LG Y40 1.39x39 TM1 Van der Waals
GPR15LG F82 2.53x53 TM2 hydrophobic
GPR15LG W89 2.60x60 TM2 Van der Waals
GPR15LG K92 2.63x63 TM2 Van der Waals
GPR15LG I113 3.32x32 TM3 hydrophobic
GPR15LG S114 3.33x33 TM3 Van der Waals
GPR15LG M117 3.36x36 TM3 hydrophobic
GPR15LG R172 4.64x64 TM4 Van der Waals
GPR15LG E173 ECL2 Van der Waals
GPR15LG T175 ECL2 hydrophobic
GPR15LG Y182 ECL2 hydrophobic
GPR15LG A184 45.51x51 ECL2 hydrophobic
GPR15LG E185 45.52x52 ECL2 polar (hydrogen bond with backbone)
GPR15LG K186 ECL2 hydrophobic
GPR15LG K187 ECL2 Van der Waals
GPR15LG K192 5.35x36 TM5 polar (charge-charge)
GPR15LG K192 5.35x36 TM5 polar (hydrogen bond)
GPR15LG S196 5.39x40 TM5 polar (hydrogen bond)
GPR15LG W254 6.48x48 TM6 Van der Waals
GPR15LG F257 6.51x51 TM6 hydrophobic
GPR15LG K261 6.55x55 TM6 polar (hydrogen bond)
GPR15LG A264 6.58x58 TM6 hydrophobic
GPR15LG I265 6.59x59 TM6 hydrophobic
GPR15LG Q281 7.32x31 TM7 polar (hydrogen bond)
GPR15LG A291 7.42x41 TM7 hydrophobic
GPR15LG F292 7.43x42 TM7 Van der Waals

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ICL1 P G S R ICL1ECL1 G L W R T ECL1ICL2 P V V S R K F R ICL2ECL2 E L T L I D D K P Y C A E K K A ECL2ICL3 Y Q Q S G K H N K ICL3ECL3 G L R Q E ECL3N-term M D P E E T S V Y L D Y Y Y A T S P N S D I R E T N-termC-term K N Y D F G S S T E T S D S H L T K A L S T F I H A E D F A R R R K R S V S L C-term H S H V P Y T S V F L P V F Y T A V F L T G V L G N L V L M G A L H F K R L I D I F I I N L A A S D F I F L V T L P L W V D K E A S L G S F L C K G S S Y M I S V N M H C S V L L L T C M S V D R Y L A I V W R T D C A Y V V C A S I W F I S C L L G L P T L L S R T P I K L I W S L V A L I F T F F V P L L S I V T C Y C C I A R K L C A H K L K K S I K I I F I V V A A F L V S W L P F N T F K F L A I V S H Y L P S A I L Q L G M E V S G P L A F A N S C V N P F I Y Y I F D S Y I V H C L I R R A C L C P
Helix box plot — Download: PNG | SVG L N G L V G T L F V A T Y F V P L F V S 1 I N L A A S D F I F L V T L P L W V D K 2 C T L L L V S C H M N V S I M Y S S G K 3 A Y V V C A S I W F I S C L L G L P T L 4 Y C T V I S L L P V F F T F I L A V L S W 5 F I V V A A F L V S W L P F N T F K F L 6 F P N V C S N A F A L P G S V E M G L 7

GPCRdb(A)
GPCRdb(A)
GPR15
TM1
1x39 1.39x39 Y40
TM2
2x53 2.53x53 F82
2x60 2.60x60 W89
2x63 2.63x63 K92
TM3
3x32 3.32x32 I113
3x33 3.33x33 S114
3x36 3.36x36 M117
TM4
4x64 4.64x64 R172
ECL2
45x51 45.51x51 A184
45x52 45.52x52 E185
TM5
5x36 5.35x36 K192
5x40 5.39x40 S196
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x55 6.55x55 K261
6x58 6.58x58 A264
6x59 6.59x59 I265
TM7
7x31 7.32x31 Q281
7x41 7.42x41 A291
7x42 7.43x42 F292