PDB
9X22
Resolution
2.9 Å
Released
March 25, 2026
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
[125I]GLP-1-(7-36)-amide
Function
Agonist
Reference
10.1016/J.APSB.2026.01.023

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Ligand Amino Acid Generic Number Segment Interaction Type
[125I]GLP-1-(7-36)-amide L32 N-term polar (hydrogen bond with backbone)
[125I]GLP-1-(7-36)-amide L32 N-term Van der Waals
[125I]GLP-1-(7-36)-amide T35 N-term Van der Waals
[125I]GLP-1-(7-36)-amide V36 N-term Van der Waals
[125I]GLP-1-(7-36)-amide V36 N-term hydrophobic
[125I]GLP-1-(7-36)-amide W39 N-term aromatic (face-to-edge)
[125I]GLP-1-(7-36)-amide W39 N-term Van der Waals
[125I]GLP-1-(7-36)-amide E68 N-term polar (charge-assisted hydrogen bond)
[125I]GLP-1-(7-36)-amide Y69 N-term Van der Waals
[125I]GLP-1-(7-36)-amide Y69 N-term hydrophobic
[125I]GLP-1-(7-36)-amide Y88 N-term hydrophobic
[125I]GLP-1-(7-36)-amide Y88 N-term Van der Waals
[125I]GLP-1-(7-36)-amide P90 N-term hydrophobic
[125I]GLP-1-(7-36)-amide P90 N-term Van der Waals
[125I]GLP-1-(7-36)-amide W91 N-term Van der Waals
[125I]GLP-1-(7-36)-amide W91 N-term hydrophobic
[125I]GLP-1-(7-36)-amide R121 N-term polar (charge-assisted hydrogen bond)
[125I]GLP-1-(7-36)-amide E138 1.33x33 TM1 Van der Waals
[125I]GLP-1-(7-36)-amide L141 1.36x36 TM1 Van der Waals
[125I]GLP-1-(7-36)-amide L141 1.36x36 TM1 hydrophobic
[125I]GLP-1-(7-36)-amide L144 1.39x39 TM1 hydrophobic
[125I]GLP-1-(7-36)-amide L144 1.39x39 TM1 Van der Waals
[125I]GLP-1-(7-36)-amide Y145 1.40x40 TM1 hydrophobic
[125I]GLP-1-(7-36)-amide Y145 1.40x40 TM1 Van der Waals
[125I]GLP-1-(7-36)-amide Y148 1.43x43 TM1 Van der Waals
[125I]GLP-1-(7-36)-amide Y148 1.43x43 TM1 aromatic (edge-to-face)
[125I]GLP-1-(7-36)-amide Y152 1.47x47 TM1 polar (hydrogen bond)
[125I]GLP-1-(7-36)-amide R190 2.60x60 TM2 polar (charge-assisted hydrogen bond)
[125I]GLP-1-(7-36)-amide K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
[125I]GLP-1-(7-36)-amide L201 2.71x71 TM2 hydrophobic
[125I]GLP-1-(7-36)-amide L201 2.71x71 TM2 Van der Waals
[125I]GLP-1-(7-36)-amide Y205 2.75x75 TM2 polar (hydrogen bond)
[125I]GLP-1-(7-36)-amide Y205 2.75x75 TM2 polar (hydrogen bond)
[125I]GLP-1-(7-36)-amide Q210 ECL1 Van der Waals
[125I]GLP-1-(7-36)-amide W214 ECL1 hydrophobic
[125I]GLP-1-(7-36)-amide W214 ECL1 Van der Waals
[125I]GLP-1-(7-36)-amide Q221 ECL1 Van der Waals
[125I]GLP-1-(7-36)-amide M233 3.36x36 TM3 Van der Waals
[125I]GLP-1-(7-36)-amide Q234 3.37x37 TM3 Van der Waals
[125I]GLP-1-(7-36)-amide Q234 3.37x37 TM3 polar (hydrogen bond)
[125I]GLP-1-(7-36)-amide V237 3.40x40 TM3 hydrophobic
[125I]GLP-1-(7-36)-amide V237 3.40x40 TM3 Van der Waals
[125I]GLP-1-(7-36)-amide Y241 3.44x44 TM3 Van der Waals
[125I]GLP-1-(7-36)-amide T298 45.52x52 ECL2 Van der Waals
[125I]GLP-1-(7-36)-amide R299 ECL2 polar (charge-assisted hydrogen bond)
[125I]GLP-1-(7-36)-amide N300 ECL2 polar (hydrogen bond)
[125I]GLP-1-(7-36)-amide N300 ECL2 Van der Waals
[125I]GLP-1-(7-36)-amide N300 ECL2 polar (hydrogen bond with backbone)
[125I]GLP-1-(7-36)-amide W306 5.36x37 TM5 Van der Waals
[125I]GLP-1-(7-36)-amide W306 5.36x37 TM5 aromatic (edge-to-face)
[125I]GLP-1-(7-36)-amide I309 5.39x39 TM5 Van der Waals
[125I]GLP-1-(7-36)-amide I313 5.43x43 TM5 hydrophobic
[125I]GLP-1-(7-36)-amide D372 ECL3 Van der Waals
[125I]GLP-1-(7-36)-amide R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
[125I]GLP-1-(7-36)-amide L384 7.39x38 TM7 hydrophobic
[125I]GLP-1-(7-36)-amide L384 7.39x38 TM7 Van der Waals
[125I]GLP-1-(7-36)-amide E387 7.42x41 TM7 Van der Waals
[125I]GLP-1-(7-36)-amide L388 7.43x42 TM7 hydrophobic
[125I]GLP-1-(7-36)-amide L388 7.43x42 TM7 Van der Waals

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x32 3.36x36 M233
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x43 5.39x39 I309
5x47 5.43x43 I313
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388