PDB
9X3Y
Resolution
2.8 Å
Released
April 15, 2026
Receptor
MAS1
Class
A
Species
Homo sapiens
Ligand
neuropeptide FF (Human)
Function
Agonist
Reference
10.1038/S44318-026-00764-6

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Ligand Amino Acid Generic Number Segment Interaction Type
neuropeptide FF (Human) H36 1.36x36 TM1 aromatic (edge-to-face)
neuropeptide FF (Human) I84 2.57x57 TM2 hydrophobic
neuropeptide FF (Human) L87 2.60x60 TM2 hydrophobic
neuropeptide FF (Human) Y91 2.64x64 TM2 Van der Waals
neuropeptide FF (Human) Y91 2.64x64 TM2 polar (hydrogen bond)
neuropeptide FF (Human) Y95 ECL1 Van der Waals
neuropeptide FF (Human) Y95 ECL1 hydrophobic
neuropeptide FF (Human) S109 3.29x29 TM3 Van der Waals
neuropeptide FF (Human) F112 3.32x32 TM3 Van der Waals
neuropeptide FF (Human) F112 3.32x32 TM3 hydrophobic
neuropeptide FF (Human) Y168 4.61x61 TM4 hydrophobic
neuropeptide FF (Human) I172 ECL2 Van der Waals
neuropeptide FF (Human) I172 ECL2 hydrophobic
neuropeptide FF (Human) Y248 6.55x55 TM6 hydrophobic
neuropeptide FF (Human) Y248 6.55x55 TM6 Van der Waals
neuropeptide FF (Human) Y251 6.58x58 TM6 polar (hydrogen bond)
neuropeptide FF (Human) Y251 6.58x58 TM6 Van der Waals
neuropeptide FF (Human) Y252 6.59x59 TM6 Van der Waals
neuropeptide FF (Human) H262 7.35x34 TM7 polar (hydrogen bond)
neuropeptide FF (Human) H262 7.35x34 TM7 Van der Waals
neuropeptide FF (Human) H263 7.36x35 TM7 aromatic (face-to-edge)
neuropeptide FF (Human) H263 7.36x35 TM7 Van der Waals
neuropeptide FF (Human) L266 7.39x38 TM7 hydrophobic
neuropeptide FF (Human) L266 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R ICL1ECL1 Y E L ECL1ICL2 P I W Y R C H R ICL2ECL2 I D R E E E S H S R N ECL2ICL3 A S H ICL3ECL3 W S T F ECL3N-term M D G S N V T S F V V E E P T N I S T G R N A S V G N A H R Q N-termC-term L T R A F K D E M Q P R R Q K D N C N T V T V E T V V C-term I P I V H W V I M S I S P V G F V E N G I L L W F L C F R M N P F T V Y I T H L S I A D I S L L F C I F I L S I D Y A L D S S G H Y Y T I V T L S V T F L F G Y N T G L Y L L T A I S V E R C L S V L Y P K Y Q S A L V C A L L W A L S C L V T T M E Y V M C D C R A V I I F I A I L S F L V F T P L M L V S S T I L V V K I R K N T W S S K L Y I V I M V T I I I F L I F A M P M R L L Y L L Y Y E Y G N L H H I S L L F S T I N S S A N P F I Y F F V G S S F K E V K K K R S L K V
Helix box plot — Download: PNG | SVG G N E V F G V P S I S M I V W H V I P I 1 T H L S I A D I S L L F C I F I L S I D 2 A T L L Y L G T N Y G F L F T V S L T V 3 S A L V C A L L W A L S C L V T T M E Y 4 I T S S V L M L P T F V L F S L I A I F I 5 M V T I I I F L I F A M P M R L L Y L L 6 F P N A S S N I T S F L L S I H H L N 7

GPCRdb(A)
GPCRdb(A)
MAS1
TM1
1x36 1.36x36 H36
TM2
2x57 2.57x57 I84
2x60 2.60x60 L87
2x64 2.64x64 Y91
TM3
3x29 3.29x29 S109
3x32 3.32x32 F112
TM4
4x61 4.61x61 Y168
TM6
6x55 6.55x55 Y248
6x58 6.58x58 Y251
6x59 6.59x59 Y252
TM7
7x34 7.35x34 H262
7x35 7.36x35 H263
7x38 7.39x38 L266