PDB
9XHH
Resolution
3.0 Å
Released
April 22, 2026
Receptor
CCR7
Class
A
Species
Homo sapiens
Ligand
Function
C-C motif chemokine 19
Agonist
Reference
10.1073/PNAS.2533975123

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Ligand Amino Acid Generic Number Segment Interaction Type
C-C motif chemokine 19 V39 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 19 Y41 N-term Van der Waals
C-C motif chemokine 19 L43 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 19 F44 N-term hydrophobic
C-C motif chemokine 19 E45 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 19 E45 N-term hydrophobic
C-C motif chemokine 19 E45 N-term polar (hydrogen bond)
C-C motif chemokine 19 S46 N-term Van der Waals
C-C motif chemokine 19 L47 N-term hydrophobic
C-C motif chemokine 19 C48 N-term Van der Waals
C-C motif chemokine 19 S49 N-term Van der Waals
C-C motif chemokine 19 K50 N-term hydrophobic
C-C motif chemokine 19 K50 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 19 V53 N-term hydrophobic
C-C motif chemokine 19 R54 N-term polar (charge-charge)
C-C motif chemokine 19 R54 N-term polar (hydrogen bond)
C-C motif chemokine 19 K57 1.31x31 TM1 polar (charge-charge)
C-C motif chemokine 19 W114 2.60x60 TM2 Van der Waals
C-C motif chemokine 19 F133 3.29x29 TM3 Van der Waals
C-C motif chemokine 19 Y136 3.32x32 TM3 hydrophobic
C-C motif chemokine 19 Q200 ECL2 polar (hydrogen bond)
C-C motif chemokine 19 S202 ECL2 Van der Waals
C-C motif chemokine 19 S203 ECL2 Van der Waals
C-C motif chemokine 19 S204 ECL2 Van der Waals
C-C motif chemokine 19 R209 ECL2 polar (charge-charge)
C-C motif chemokine 19 R209 ECL2 polar (hydrogen bond)
C-C motif chemokine 19 C210 45.50x50 ECL2 Van der Waals
C-C motif chemokine 19 S211 45.51x51 ECL2 polar (hydrogen bond)
C-C motif chemokine 19 F220 5.35x36 TM5 aromatic (pi-cation)
C-C motif chemokine 19 N290 6.62x62 TM6 Van der Waals
C-C motif chemokine 19 S296 ECL3 Van der Waals
C-C motif chemokine 19 T297 7.24x23 TM7 Van der Waals
C-C motif chemokine 19 C298 7.25x24 TM7 hydrophobic
C-C motif chemokine 19 N305 7.32x31 TM7 Van der Waals
C-C motif chemokine 19 Y308 7.35x34 TM7 hydrophobic
C-C motif chemokine 19 D309 7.36x35 TM7 polar (hydrogen bond)
C-C motif chemokine 19 Y312 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K R L K ICL1ECL1 S W V F ECL1ICL2 A V S A H R H R A R ICL2ECL2 D L Q R S S S E Q A M R C S L I T E H V ECL2ICL3 R N ICL3ECL3 T S S ECL3N-term M D L G K P M K S V L V V A L L V I F Q V C L C Q D E V T D D Y I G D N T T V D Y T L F E S L C S K K D V R N-termC-term D L G C L S Q E Q L R Q W S S C R H I R R S S M S V E A E T T T T F S P C-term N F K A W F L P I M Y S I I C F V G L L G N G L V V L T Y I Y F T M T D T Y L L N L A V A D I L F L L T L P F W A Y S A A K G V H F C K L I F A I Y K M S F F S G M L L L L C I S I D R Y V A I V Q V L L I S K L S C V G I W I L A T V L S I P E L L Y S E A F I T I Q V A Q M V I G F L V P L L A M S F C Y L V I I R T L L Q A F E R N K A I K V I I A V V V V F I V F Q L P Y N G V V L A Q T V A N F N I T C E L S K Q L N I A Y D V T Y S L A C V R C C V N P F L Y A F I G V K L F K F R N D L F K
Helix box plot — Download: PNG | SVG G N G L L G V F C I I S Y M I P L F W A 1 L N L A V A D I L F L L T L P F W A Y S 2 C L L L L M G S F F S M K Y I A F I L K 3 S K L S C V G I W I L A T V L S I P E 4 Y C F S M A L L P V L F G I V M Q A V Q I 5 I A V V V V F I V F Q L P Y N G V V L A 6 F P N V C C R V C A L S Y T V D Y A I 7

GPCRdb(A)
GPCRdb(A)
CCR7
TM1
1x31 1.31x31 K57
TM2
2x60 2.60x60 W114
TM3
3x29 3.29x29 F133
3x32 3.32x32 Y136
ECL2
45x50 45.50x50 C210
45x51 45.51x51 S211
TM5
5x36 5.35x36 F220
TM6
6x62 6.62x62 N290
TM7
7x23 7.24x23 T297
7x24 7.25x24 C298
7x31 7.32x31 N305
7x34 7.35x34 Y308
7x35 7.36x35 D309
7x38 7.39x38 Y312