PDB
9XHI
Resolution
3.2 Å
Released
April 22, 2026
Receptor
CCR7
Class
A
Species
Homo sapiens
Ligand
Function
C-C motif chemokine 21
Agonist
Reference
10.1073/PNAS.2533975123

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Ligand Amino Acid Generic Number Segment Interaction Type
C-C motif chemokine 21 V39 N-term hydrophobic
C-C motif chemokine 21 Y41 N-term hydrophobic
C-C motif chemokine 21 L43 N-term Van der Waals
C-C motif chemokine 21 F44 N-term hydrophobic
C-C motif chemokine 21 E45 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 21 E45 N-term hydrophobic
C-C motif chemokine 21 S46 N-term polar (hydrogen bond)
C-C motif chemokine 21 L47 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 21 L47 N-term hydrophobic
C-C motif chemokine 21 C48 N-term Van der Waals
C-C motif chemokine 21 S49 N-term Van der Waals
C-C motif chemokine 21 K50 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 21 V53 N-term hydrophobic
C-C motif chemokine 21 R54 N-term polar (charge-charge)
C-C motif chemokine 21 R54 N-term polar (hydrogen bond)
C-C motif chemokine 21 R54 N-term hydrophobic
C-C motif chemokine 21 K57 1.31x31 TM1 polar (charge-charge)
C-C motif chemokine 21 W114 2.60x60 TM2 aromatic (pi-cation)
C-C motif chemokine 21 F133 3.29x29 TM3 hydrophobic
C-C motif chemokine 21 Q200 ECL2 polar (hydrogen bond)
C-C motif chemokine 21 S202 ECL2 Van der Waals
C-C motif chemokine 21 R209 ECL2 Van der Waals
C-C motif chemokine 21 L212 45.52x52 ECL2 polar (hydrogen bond with backbone)
C-C motif chemokine 21 L212 45.52x52 ECL2 hydrophobic
C-C motif chemokine 21 I213 ECL2 hydrophobic
C-C motif chemokine 21 T214 ECL2 Van der Waals
C-C motif chemokine 21 V217 5.32x33 TM5 Van der Waals
C-C motif chemokine 21 F220 5.35x36 TM5 hydrophobic
C-C motif chemokine 21 Q286 6.58x58 TM6 polar (hydrogen bond)
C-C motif chemokine 21 N290 6.62x62 TM6 polar (hydrogen bond)
C-C motif chemokine 21 S295 ECL3 Van der Waals
C-C motif chemokine 21 S296 ECL3 Van der Waals
C-C motif chemokine 21 T297 7.24x23 TM7 Van der Waals
C-C motif chemokine 21 C298 7.25x24 TM7 hydrophobic
C-C motif chemokine 21 S301 7.28x27 TM7 Van der Waals
C-C motif chemokine 21 N305 7.32x31 TM7 polar (hydrogen bond)
C-C motif chemokine 21 Y308 7.35x34 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 K R L K ICL1ECL1 S W V F ECL1ICL2 A V S A H R H R A R ICL2ECL2 D L Q R S S S E Q A M R C S L I T E H V ECL2ICL3 R N ICL3ECL3 T S S ECL3N-term M D L G K P M K S V L V V A L L V I F Q V C L C Q D E V T D D Y I G D N T T V D Y T L F E S L C S K K D V R N-termC-term D L G C L S Q E Q L R Q W S S C R H I R R S S M S V E A E T T T T F S P C-term N F K A W F L P I M Y S I I C F V G L L G N G L V V L T Y I Y F T M T D T Y L L N L A V A D I L F L L T L P F W A Y S A A K G V H F C K L I F A I Y K M S F F S G M L L L L C I S I D R Y V A I V Q V L L I S K L S C V G I W I L A T V L S I P E L L Y S E A F I T I Q V A Q M V I G F L V P L L A M S F C Y L V I I R T L L Q A F E R N K A I K V I I A V V V V F I V F Q L P Y N G V V L A Q T V A N F N I T C E L S K Q L N I A Y D V T Y S L A C V R C C V N P F L Y A F I G V K L F K F R N D L F K
Helix box plot — Download: PNG | SVG G N G L L G V F C I I S Y M I P L F W A 1 L N L A V A D I L F L L T L P F W A Y S 2 C L L L L M G S F F S M K Y I A F I L K 3 S K L S C V G I W I L A T V L S I P E 4 Y C F S M A L L P V L F G I V M Q A V Q I 5 I A V V V V F I V F Q L P Y N G V V L A 6 F P N V C C R V C A L S Y T V D Y A I 7

GPCRdb(A)
GPCRdb(A)
CCR7
TM1
1x31 1.31x31 K57
TM2
2x60 2.60x60 W114
TM3
3x29 3.29x29 F133
ECL2
45x52 45.52x52 L212
TM5
5x36 5.35x36 F220
TM6
6x58 6.58x58 Q286
6x62 6.62x62 N290
TM7
7x23 7.24x23 T297
7x24 7.25x24 C298
7x27 7.28x27 S301
7x31 7.32x31 N305
7x34 7.35x34 Y308