PDB
9XXT
Resolution
2.0 Å
Released
April 15, 2026
Receptor
GPR174
Class
A
Species
Homo sapiens
Ligand
lysophosphatidylserine
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
lysophosphatidylserine Y22 1.35x35 TM1 hydrophobic
lysophosphatidylserine R75 2.60x60 TM2 polar (charge-assisted hydrogen bond)
lysophosphatidylserine Y79 2.64x64 TM2 Van der Waals
lysophosphatidylserine Y79 2.64x64 TM2 polar (hydrogen bond)
lysophosphatidylserine Y99 3.33x33 TM3 polar (hydrogen bond)
lysophosphatidylserine Y99 3.33x33 TM3 polar (hydrogen bond)
lysophosphatidylserine Y103 3.37x37 TM3 Van der Waals
lysophosphatidylserine Y103 3.37x37 TM3 hydrophobic
lysophosphatidylserine I145 4.53x53 TM4 Van der Waals
lysophosphatidylserine I145 4.53x53 TM4 hydrophobic
lysophosphatidylserine F152 4.60x60 TM4 hydrophobic
lysophosphatidylserine F152 4.60x60 TM4 Van der Waals
lysophosphatidylserine L155 4.63x63 TM4 hydrophobic
lysophosphatidylserine L155 4.63x63 TM4 Van der Waals
lysophosphatidylserine R156 4.64x64 TM4 polar (charge-assisted hydrogen bond)
lysophosphatidylserine F169 45.51x51 ECL2 Van der Waals
lysophosphatidylserine V170 45.52x52 ECL2 Van der Waals
lysophosphatidylserine M185 5.38x39 TM5 Van der Waals
lysophosphatidylserine G189 5.42x43 TM5 Van der Waals
lysophosphatidylserine I192 5.45x46 TM5 hydrophobic
lysophosphatidylserine I192 5.45x46 TM5 Van der Waals
lysophosphatidylserine Y246 6.51x51 TM6 polar (hydrogen bond)
lysophosphatidylserine F250 6.55x55 TM6 hydrophobic
lysophosphatidylserine F250 6.55x55 TM6 Van der Waals
lysophosphatidylserine F254 6.59x59 TM6 hydrophobic
lysophosphatidylserine F254 6.59x59 TM6 Van der Waals
lysophosphatidylserine K257 6.62x62 TM6 polar (charge-assisted hydrogen bond)
lysophosphatidylserine H274 7.35x34 TM7 Van der Waals
lysophosphatidylserine L278 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K R A ICL1ECL1 D W P F ECL1ICL2 P F R F H D C ICL2ECL2 T S D D T S G N R T K C F V D L P T R N V ECL2ICL3 Q D K Y P M A Q D L ICL3ECL3 E I K ECL3N-term M P A N Y T C T R P D G D N T D N-termC-term H D S I Q L H A K S F V S N H T A S T M T P E L C C-term F R Y F I Y A V T Y T V I L V P G L I G N I L A L W V F Y G Y M K E T V I F M I N L A I A D L L Q V L S L P L R I F Y Y L N H G P G L C M F C F Y L K Y V N M Y A S I Y F L V C I S V R R F W F L M Y K Q K Y D L Y I S I A G W L I I C L A C V L F P L L R N L A Q S V V M M T I G E L I G F V T P L L I V L Y C T W K T V L S L G E K Q K A L K M I L T C A G V F L I C F A P Y H F S F P L D F L V K S N S C L A R R V I L I F H S V A L C L A S L N S C L D P V I Y Y F S T N E L S R F R R R Q D L
Helix box plot — Download: PNG | SVG I N G I L G P V L I V T Y T V A Y I F Y 1 I N L A I A D L L Q V L S L P L R I F Y 2 C V L F Y I S A Y M N V Y K L Y F C F M 3 D L Y I S I A G W L I I C L A C V L F P 4 T C Y L V I L L P T V F G I L E G I T M M 5 L T C A G V F L I C F A P Y H F S F P L 6 V P D L C S N L S A L C L A V S H F I 7

GPCRdb(A)
GPCRdb(A)
GPR174
TM1
1x35 1.35x35 Y22
TM2
2x60 2.60x60 R75
2x64 2.64x64 Y79
TM3
3x33 3.33x33 Y99
3x37 3.37x37 Y103
TM4
4x53 4.53x53 I145
4x60 4.60x60 F152
4x63 4.63x63 L155
4x64 4.64x64 R156
ECL2
45x51 45.51x51 F169
45x52 45.52x52 V170
TM5
5x39 5.38x39 M185
5x43 5.42x43 G189
5x46 5.45x46 I192
TM6
6x51 6.51x51 Y246
6x55 6.55x55 F250
6x59 6.59x59 F254
6x62 6.62x62 K257
TM7
7x34 7.35x34 H274
7x38 7.39x38 L278