PDB
9YDU
Resolution
3.2 Å
Released
Nov. 19, 2025
Receptor
P2Y14
Class
A
Species
Homo sapiens
Ligand
Function
UDP-glucose
Agonist
Reference
10.1038/S42003-025-09174-6

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Ligand Amino Acid Generic Number Segment Interaction Type
UDP-glucose K77 2.60x60 TM2 Van der Waals
UDP-glucose D81 2.64x64 TM2 polar (hydrogen bond)
UDP-glucose V93 3.24x24 TM3 Van der Waals
UDP-glucose C94 3.25x25 TM3 polar (hydrogen bond with backbone)
UDP-glucose A98 3.29x29 TM3 Van der Waals
UDP-glucose V99 3.30x30 TM3 Van der Waals
UDP-glucose Y102 3.33x33 TM3 polar (hydrogen bond)
UDP-glucose Y102 3.33x33 TM3 hydrophobic
UDP-glucose Y106 3.37x37 TM3 Van der Waals
UDP-glucose N156 4.60x60 TM4 polar (hydrogen bond)
UDP-glucose T160 4.64x64 TM4 Van der Waals
UDP-glucose I170 ECL2 Van der Waals
UDP-glucose C172 45.50x50 ECL2 Van der Waals
UDP-glucose H184 5.36x36 TM5 polar (hydrogen bond)
UDP-glucose H184 5.36x36 TM5 aromatic (edge-to-face)
UDP-glucose S187 5.39x39 TM5 Van der Waals
UDP-glucose N188 5.40x40 TM5 Van der Waals
UDP-glucose F191 5.43x43 TM5 Van der Waals
UDP-glucose R253 6.55x55 TM6 polar (hydrogen bond)
UDP-glucose R253 6.55x55 TM6 polar (charge-charge)
UDP-glucose Y256 6.58x58 TM6 polar (hydrogen bond)
UDP-glucose K277 7.35x34 TM7 polar (charge-charge)
UDP-glucose K277 7.35x34 TM7 polar (hydrogen bond)
UDP-glucose E278 7.36x35 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P S S ICL1ECL1 L G P ECL1ICL2 P L W T S F I Q ICL2ECL2 N Q S V R E V T Q I K C I E L K S ECL2ICL3 L K S ICL3ECL3 A H Y ECL3N-term M I N S T S T Q P P D E S C S Q N N-termC-term L H I P L K A Q N D L D I S R I K R G N T T L E S T D T L C-term L L I T Q Q I I P V L Y C M V F I A G I L L N G V S G W I F F Y V K S F I I Y L K N I V I A D F V M S L T F P F K I L G D S G W Q L N V F V C R V S A V L F Y V N M Y V S I V F F G L I S F D R Y Y K I V K S V S Y S K L L S V I V W M L M L L L A V P N I I L T E L G R K W H K A S N Y I F V A I F W I V F L L L I V F Y T A I T K K I F K S H S R N S T S V K K K S S R N I F S I V F V F F V C F V P Y H I A R I P Y T K S Q T E S C Q S K E I L R Y M K E F T L L L S A A N V C L D P I I Y F F L C Q P L C K F R E I K
Helix box plot — Download: PNG | SVG G N L L I G A I F V M C Y L V P I I Q Q 1 K N I V I A D F V M S L T F P F K I L G 2 L G F F V I S V Y M N V Y F L V A S V R 3 S K L L S V I V W M L M L L L A V P N I 4 Y F V I L L L F V I W F I A V F I Y N S 5 I F S I V F V F V F C F V P Y H I A R I P 6 I P D L C V N A A S L L L T F E K M Y 7

GPCRdb(A)
GPCRdb(A)
P2Y14 receptor
TM2
2x60 2.60x60 K77
2x64 2.64x64 D81
TM3
3x24 3.24x24 V93
3x25 3.25x25 C94
3x29 3.29x29 A98
3x30 3.30x30 V99
3x33 3.33x33 Y102
3x37 3.37x37 Y106
TM4
4x60 4.60x60 N156
4x64 4.64x64 T160
ECL2
45x50 45.50x50 C172
TM5
5x36 5.36x36 H184
5x39 5.39x39 S187
5x40 5.40x40 N188
5x43 5.43x43 F191
TM6
6x55 6.55x55 R253
6x58 6.58x58 Y256
TM7
7x34 7.35x34 K277
7x35 7.36x35 E278