PDB
9YFU
Resolution
3.1 Å
Released
March 25, 2026
Receptor
GPR61
Class
A
Species
Homo sapiens
Ligand
Function
GPR61 inverse agonist 15
Inverse agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
GPR61 inverse agonist 15 N137 3.47x47 TM3 polar (hydrogen bond)
GPR61 inverse agonist 15 R140 3.50x50 TM3 polar (hydrogen bond)
GPR61 inverse agonist 15 R140 3.50x50 TM3 hydrophobic
GPR61 inverse agonist 15 I224 5.54x54 TM5 Van der Waals
GPR61 inverse agonist 15 V227 5.57x57 TM5 Van der Waals
GPR61 inverse agonist 15 Y228 5.58x58 TM5 Van der Waals
GPR61 inverse agonist 15 M231 5.61x61 TM5 Van der Waals
GPR61 inverse agonist 15 V354 6.35x35 TM6 Van der Waals
GPR61 inverse agonist 15 V355 6.36x36 TM6 hydrophobic
GPR61 inverse agonist 15 A358 6.39x39 TM6 hydrophobic
GPR61 inverse agonist 15 V359 6.40x40 TM6 Van der Waals
GPR61 inverse agonist 15 F407 7.52x52 TM7 Van der Waals
GPR61 inverse agonist 15 L411 ICL4 hydrophobic
GPR61 inverse agonist 15 N412 8.47x47 H8 Van der Waals

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ICL1 P A L R ICL1ECL1 F D H A L ECL1ICL2 P M R Y E V R M ICL2ECL2 E G A P S V P P G C S L Q W S H ECL2ICL3 T W M E T P R Q R S E S L S S R S T M V T S S G A P Q T T ICL3ECL3 A Q P I S ECL3N-term M E S S P I P Q S S G N S S T L G R V P Q T P G P S T A S G V P E V G N-termC-term C F F K P A P E E E L R L P S R E G S I E E N F L Q F L Q G T G C P S E S W V S R P L P S P K Q E P P A V D F R I P G Q I A E E T S E F L E Q Q L T S D I I M S D S Y L R P A A S P R L E S C-term L R D V A S E S V A L F F M L L L D L T A V A G N A A V M A V I A K T K F V F V F H L C L V D L L A A L T L M P L A M L S S S A L F G E V A C R L Y L F L S V C F V S L A I L S V S A I N V E R Y Y Y V V H T L G L V A S V L V G V W V K A L A M A S V P V L G R V S W E S A Y C Q L F V V V F A V L Y F L L P L L L I L V V Y C S M F R V A R V A A M Q H G P L P P H R T F G G G K A A V V L L A V G G Q F L L C W L P Y F S F H L Y V A L S T G Q V E S V V T W I G Y F C F T S N P F F Y G C L N R Q L S K I R G E Q F V
Helix box plot — Download: PNG | SVG A N G A V A T L D L L L M F F L A V S E 1 F H L C L V D L L A A T L L M P L A M L S 2 A S V S L I A L S V F C V S L F L Y L R 3 V A S V L V G V W V K A L A M A S V P V 4 Y V V L I L L L P L L F Y L V A F V V V F 5 L A V G G Q F L L C W L P Y F S F H L Y 6 F P N S T F C F Y G I W T V V S E V Q 7

GPCRdb(A)
GPCRdb(A)
GPR61
TM3
3x47 3.47x47 N137
3x50 3.50x50 R140
TM5
5x54 5.54x54 I224
5x57 5.57x57 V227
5x58 5.58x58 Y228
5x61 5.61x61 M231
TM6
6x35 6.35x35 V287
6x36 6.36x36 V288
6x39 6.39x39 A291
6x40 6.40x40 V292
TM7
7x52 7.52x52 F340
H8
8x47 8.47x47 N345