Compound 2 [Pmid: 21105727]


SMILES O/N=C\1/c2ccccc2OC2(C1C2)C(=O)Nc1ccc(cc1)Cl
InChIKey ZRURMLHGCOJTNX-HKWRFOASSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 328.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.0 6.0 6.0 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.0 6.0 6.0 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 6.1 6.1 6.1 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 4.9 4.9 4.9 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 6.1 6.1 6.1 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 4.87 4.87 4.87 ChEMBL