GPCRdb

ASENAPINE

Agent/drug
Bioactivity

ASENAPINE

SMILES	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1
InChIKey	VSWBSWWIRNCQIJ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	0
Molecular weight (Da)	285.1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem PubChem ChEMBL_compound_ids PubChem DrugBank PubChem PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.05	8.05	8.05	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.41	8.41	8.41	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.08	8.08	8.08	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.36	8.36	8.36	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.98	8.09	8.19	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.97	8.64	9.31	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.06	8.06	8.06	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.75	7.82	7.89	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.30	5.30	5.30	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.30	5.30	5.30	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
δ	OPRD	Mouse	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
κ	OPRK	Guinea pig	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
κ	OPRK	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Rat	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.27	7.70	8.00	PDSP Ki database

Showing 1 to 20 of 87 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₂	HRH2	Human	Histamine	A	pIC50	8.09	8.09	8.09	Drug Central

Showing 1 to 1 of 1 entry

ASENAPINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 4

Phase IV 7

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem PubChem ChEMBL_compound_ids PubChem DrugBank PubChem PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z		0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizoaffective disorder, unspecified	3	6A21.Z		0.606
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z		0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z		0.620
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z		0.660
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Schizoaffective disorder, unspecified	3	6A21.Z		0.606
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z		0.615
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z		0.732

Showing 1 to 8 of 8 entries