compound 46 [PMID: 25268943]


SMILES NC(=N)NCCNC(=O)C1(CCN(CC1)Cc1ccccc1)Nc1ccccc1
InChIKey SCPYAGLHLAAYFP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 5
Rotatable bonds 8
Molecular weight (Da) 394.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Guinea pig Histamine A pKd 7.2 7.2 7.2 ChEMBL
H1 HRH1 Guinea pig Histamine A pKd 4.7 4.7 4.7 ChEMBL
H3 HRH3 Rat Histamine A pKi 7.48 7.49 7.5 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pEC50 7.01 7.01 7.01 ChEMBL