sufugolix


SMILES CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1
InChIKey UCQSBGOFELXYIN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 10
Molecular weight (Da) 667.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A1 AA1R Rat Adenosine A pKi 4.55 4.55 4.55 Guide to Pharmacology
A2B AA2BR Rat Adenosine A pKi 5.09 5.09 5.09 Guide to Pharmacology
A3 AA3R Rat Adenosine A pKi 5.0 5.0 5.0 Guide to Pharmacology
A2A AA2AR Rat Adenosine A pKi 7.27 7.49 8.04 ChEMBL
A1 AA1R Rat Adenosine A pKi 4.55 4.55 4.55 ChEMBL
A2A AA2AR Human Adenosine A pKi 6.69 7.21 7.44 ChEMBL
A2B AA2BR Human Adenosine A pKi 5.09 5.09 5.09 ChEMBL
A2A AA2AR Rat Adenosine A pKi 7.27 7.27 7.27 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database