orforglipron


SMILES C[C@H]1C[C@]1(c1noc(=O)[nH]1)n1c2c(cc(cc2)[C@H]2CCOC(C2)(C)C)cc1C(=O)N1CCc2nn(c(c2[C@@H]1C)n1ccn(c1=O)c1c(c2c(cc1)n(nc2)C)F)c1cc(c(c(c1)C)F)C
InChIKey USUWIEBBBWHKNI-KHIFEHGGSA-N

Chemical properties

Hydrogen bond acceptors 13
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 882.4

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 6XOX 7E14

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC5 MC5R Human Melanocortin A pEC50 5.85 5.85 5.85 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 7.38 7.38 7.38 ChEMBL
MC4 MC4R Human Melanocortin A pIC50 7.7 7.7 7.7 ChEMBL