GPCRdb

cyclizine

Agent/drug
Bioactivity

cyclizine

SMILES	CN1CCN(C(c2ccccc2)c2ccccc2)CC1
InChIKey	UVKZSORBKUEBAZ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	3
Molecular weight (Da)	266.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.86	5.86	5.86	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.22	6.22	6.22	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.24	6.24	6.24	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.19	7.19	7.19	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.14	8.14	8.14	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.62	6.62	6.62	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.27	6.27	6.27	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	5.99	5.99	5.99	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.22	8.22	8.22	Drug Central
H₁	HRH1	Human	Histamine	A	pKi	8.35	8.35	8.35	Guide to Pharmacology
H₁	HRH1	Human	Histamine	A	pKi	8.35	8.35	8.35	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	8.08	8.08	8.08	Drug Central
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	6.79	6.79	6.79	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.17	8.17	8.17	Drug Central
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	6.38	6.38	6.38	ChEMBL

Showing 1 to 20 of 27 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	5.60	5.60	5.60	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.92	5.92	5.92	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.81	5.81	5.81	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.65	6.65	6.65	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.43	6.43	6.43	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.99	5.99	5.99	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.52	5.52	5.52	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	7.42	7.42	7.42	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	6.17	6.17	6.17	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.94	5.94	5.94	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	6.13	6.13	6.13	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	6.07	6.07	6.07	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	6.20	6.20	6.20	ChEMBL

Showing 1 to 13 of 13 entries

cyclizine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	R06A	0.526	4	Yes

Showing 1 to 1 of 1 entry