GPCRdb

cyproheptadine

Agent/drug
Bioactivity

cyproheptadine

SMILES	CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1
InChIKey	JJCFRYNCJDLXIK-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	0
Rotatable bonds	0
Molecular weight (Da)	287.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	5-HT_2A 5-HT_2C

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.40	7.40	7.40	Guide to Pharmacology
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.01	7.01	7.01	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.60	7.60	7.60	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.36	7.36	7.36	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.28	7.28	7.28	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.97	6.97	6.97	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.77	7.77	7.77	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.73	6.73	6.73	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.16	7.16	7.16	ChEMBL
5-HT_1A	A0A4X1UTF5	Pig	5-Hydroxytryptamine	A	pKi	6.45	6.45	6.45	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.28	6.26	6.96	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.00	7.21	7.30	PDSP Ki database

Showing 1 to 20 of 106 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.62	6.62	6.62	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.18	8.18	8.18	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	7.10	7.10	7.10	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.97	6.97	6.97	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.55	6.55	6.55	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.42	7.42	7.42	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.89	5.89	5.89	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	6.91	6.91	6.91	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.16	8.16	8.16	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	5.56	5.56	5.56	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	9.01	9.01	9.01	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	8.03	8.03	8.03	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	8.61	8.61	8.61	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	6.55	6.55	6.55	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.80	6.80	6.80	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	6.85	6.85	6.85	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.79	6.79	6.79	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	8.16	8.16	8.16	Drug Central
D₃	DRD3	Human	Dopamine	A	pIC50	7.32	7.32	7.32	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	8.43	8.43	8.43	ChEMBL

Showing 1 to 20 of 28 entries

cyproheptadine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 10

Phase III 3

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	5-HT_2A 5-HT_2C

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	R06A	0.268	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Excessive weight loss	MG43.5	R06A	0.083	3	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	R06A	0.389	2	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Excessive weight loss	MG43.5	R06A	0.083	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	R06A	0.103	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	R06A	0.589	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	R06A	0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	R06A	0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Mitral valve insufficiency, unspecified	BB61.Z	R06A	0.074	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Other and unspecified abdominal pain	MD81.4	R06A	0.074	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Urticaria of unspecified type	EB05	R06A	0.606	4	Yes

Showing 1 to 11 of 11 entries