ATC0065
SMILES | Brc1ccc(c(c1)OC(F)(F)F)CCN[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C |
InChIKey | FWKVXHBRMCTKHZ-KDURUIRLSA-N |
Chemical properties
Hydrogen bond acceptors | 6 |
Hydrogen bond donors | 2 |
Rotatable bonds | 8 |
Molecular weight (Da) | 551.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
V1A | V1AR | Human | Vasopressin and oxytocin | A | pKi | 7.0 | 7.88 | 7.7 | Guide to Pharmacology |
V1B | V1BR | Human | Vasopressin and oxytocin | A | pKi | 7.7 | 8.38 | 9.4 | Guide to Pharmacology |
V2 | V2R | Human | Vasopressin and oxytocin | A | pKi | 7.2 | 8.1 | 8.6 | Guide to Pharmacology |
OT | OXYR | Human | Vasopressin and oxytocin | A | pKi | 6.7 | 7.73 | 7.6 | Guide to Pharmacology |
V1B | V1BR | Rat | Vasopressin and oxytocin | A | pKi | 8.0 | 8.0 | 8.0 | Guide to Pharmacology |
V1A | V1AR | Rat | Vasopressin and oxytocin | A | pKi | 5.6 | 5.6 | 5.6 | Guide to Pharmacology |
V2 | V2R | Rat | Vasopressin and oxytocin | A | pKi | 8.7 | 8.7 | 8.7 | Guide to Pharmacology |
V2 | V2R | Rat | Vasopressin and oxytocin | A | pKi | 9.52 | 9.52 | 9.52 | ChEMBL |
V1B | V1BR | Human | Vasopressin and oxytocin | A | pKi | 8.24 | 8.24 | 8.24 | ChEMBL |
V2 | V2R | Human | Vasopressin and oxytocin | A | pKi | 7.63 | 7.63 | 7.63 | ChEMBL |
V1A | V1AR | Human | Vasopressin and oxytocin | A | pKi | 7.21 | 7.21 | 7.21 | ChEMBL |
V1A | V1AR | Rat | Vasopressin and oxytocin | A | pKi | 7.0 | 7.0 | 7.0 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
V2 | V2R | Rat | Vasopressin and oxytocin | A | pEC50 | 10.52 | 10.52 | 10.52 | ChEMBL |
V1B | V1BR | Human | Vasopressin and oxytocin | A | pEC50 | 7.96 | 7.96 | 7.96 | ChEMBL |
V2 | V2R | Human | Vasopressin and oxytocin | A | pEC50 | 9.7 | 9.7 | 9.7 | ChEMBL |
OT | OXYR | Human | Vasopressin and oxytocin | A | pEC50 | 6.96 | 7.05 | 7.14 | ChEMBL |