SNAP-7941


SMILES COCC1=C(C(=O)OC)[C@@H](N(C(=O)N1)C(=O)NCCCN1CCC(CC1)c1cccc(c1)NC(=O)C)c1ccc(c(c1)F)F
InChIKey FWMHZWMPUWAUPL-NDEPHWFRSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 10
Molecular weight (Da) 613.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.5 6.5 6.5 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKi 7.2 7.2 7.2 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pKi 4.7 4.7 4.7 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 6.8 6.8 6.8 Guide to Pharmacology
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 7.0 7.0 7.0 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 4.1 4.1 4.1 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 4.11 4.11 4.11 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.96 6.96 6.96 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 5.5 5.5 5.5 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 4.7 4.7 4.7 Guide to Pharmacology
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 5.6 5.6 5.6 Guide to Pharmacology
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 4.4 4.4 4.4 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 6.52 6.77 7.1 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pEC50 6.46 6.71 7.35 ChEMBL
mGlu7 GRM7 Rat Metabotropic glutamate C pEC50 4.4 4.4 4.4 ChEMBL
mGlu8 GRM8 Rat Metabotropic glutamate C pEC50 4.5 4.5 4.5 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pEC50 4.64 4.64 4.64 ChEMBL