GPCRdb

Δ⁹-tetrahydrocannabinol

Agent/drug
Bioactivity

Δ⁹-tetrahydrocannabinol

SMILES	CCCCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21
InChIKey	CYQFCXCEBYINGO-IAGOWNOFSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	314.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CB₁	CNR1	Mouse	Cannabinoid	A	pKi	7.39	7.54	7.82	ChEMBL
CB₁	CNR1	Human	Cannabinoid	A	pKi	7.39	7.65	8.54	ChEMBL
CB₁	CNR1	Rat	Cannabinoid	A	pKi	5.80	7.14	7.87	PDSP Ki database
CB₁	CNR1	Human	Cannabinoid	A	pKi	7.82	7.99	8.30	PDSP Ki database
CB₁	CNR1	Mouse	Cannabinoid	A	pKi	8.08	8.08	8.08	PDSP Ki database
CB₁	CNR1	Human	Cannabinoid	A	pKi	8.07	8.07	8.07	Drug Central
CB₁	CNR1	Rat	Cannabinoid	A	pKi	8.13	8.13	8.13	Drug Central
CB₁	CNR1	Mouse	Cannabinoid	A	pKi	8.13	8.13	8.13	Drug Central
CB₁	CNR1	Human	Cannabinoid	A	pKi	7.30	7.35	7.40	Guide to Pharmacology
CB₂	CNR2	Human	Cannabinoid	A	pKi	7.10	7.30	7.50	Guide to Pharmacology
CB₂	CNR2	Mouse	Cannabinoid	A	pKi	7.40	7.56	8.04	ChEMBL
CB₂	CNR2	Human	Cannabinoid	A	pKi	7.14	7.46	8.48	ChEMBL
CB₂	CNR2	Human	Cannabinoid	A	pKi	7.35	7.77	8.50	PDSP Ki database
CB₂	CNR2	Mouse	Cannabinoid	A	pKi	7.56	8.16	8.76	PDSP Ki database
CB₂	CNR2	Rat	Cannabinoid	A	pKi	7.55	7.86	8.17	PDSP Ki database
CB₂	CNR2	Human	Cannabinoid	A	pKi	8.07	8.07	8.07	Drug Central
CB₂	CNR2	Mouse	Cannabinoid	A	pKi	8.09	8.09	8.09	Drug Central

Showing 1 to 17 of 17 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CB₁	CNR1	Mouse	Cannabinoid	A	pEC50	7.11	7.11	7.11	ChEMBL
CB₁	CNR1	Human	Cannabinoid	A	pEC50	7.11	7.42	7.77	ChEMBL
CB₁	CNR1	Human	Cannabinoid	A	pIC50	8.55	8.55	8.55	ChEMBL
CB₂	CNR2	Mouse	Cannabinoid	A	pEC50	8.14	8.14	8.14	ChEMBL
CB₂	CNR2	Human	Cannabinoid	A	pEC50	7.91	8.22	8.82	ChEMBL
CB₂	CNR2	Human	Cannabinoid	A	pIC50	8.02	8.02	8.02	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	8.10	8.10	8.10	Drug Central
D₃	DRD3	Human	Dopamine	A	pEC50	7.99	7.99	7.99	ChEMBL
GPR18	GPR18	Human	GPR18, GPR55 and GPR119	A	pEC50	6.02	6.02	6.02	Guide to Pharmacology
GPR18	GPR18	Human	GPR18, GPR55 and GPR119	A	pEC50	5.34	5.57	6.02	ChEMBL
GPR18	GPR18	Human	GPR18, GPR55 and GPR119	A	pEC50	8.22	8.22	8.22	Drug Central
GPR55	GPR55	Human	GPR18, GPR55 and GPR119	A	pEC50	8.10	8.10	8.10	Guide to Pharmacology
GPR55	GPR55	Human	GPR18, GPR55 and GPR119	A	pEC50	4.85	4.85	4.85	ChEMBL
GPR55	GPR55	Human	GPR18, GPR55 and GPR119	A	pIC50	4.85	4.85	4.85	ChEMBL
GPR55	GPR55	Human	GPR18, GPR55 and GPR119	A	pIC50	8.31	8.31	8.31	Drug Central

Showing 1 to 15 of 15 entries

Δ⁹-tetrahydrocannabinol

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 12

Phase II 34

Phase III 4

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Alcohol dependence, unspecified	6C40.2Z		0.105	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Amyotrophic lateral sclerosis	8B60.0		0.285	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Anorexia	MG43.7		0.373	4	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Anorexia Nervosa, unspecified	6B80.Z		0.266	3	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z		0.295	1	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Cannabis dependence, unspecified	6C41.2Z		0.125	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Chronic pain, unspecified	MG30.Z		0.483	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Cramp or spasm	MB47.3		0.074	1	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Essential tremor or related tremors	8A04.1		0.046	1	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified	1C62.Z		0.044	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Irritable bowel syndrome, type unspecified	DD91.0Z		0.103	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Migraine with aura, unspecified	8A80.1Z		0.074	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Migraine without aura	8A80.0		0.074	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Nausea	MD90.0		0.465	4	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Nausea or vomiting	MD90		0.280	4	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Neuropathic pain, unspecified	8E43.0Z		0.109	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Obstructive sleep apnoea	7A41		0.051	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Opioid dependence, unspecified	6C43.2Z		0.140	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Osteoarthritis, unspecified	FA0Z		0.080	3	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Pain, unspecified	MG3Z		0.517	2	Yes

Showing 1 to 20 of 43 entries

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Δ9-tetrahydrocannabinol

Δ9-tetrahydrocannabinol

Chemical Properties

Database connections

Bioactivities

Δ9-tetrahydrocannabinol

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information

Δ⁹-tetrahydrocannabinol

Δ⁹-tetrahydrocannabinol

Δ⁹-tetrahydrocannabinol