CHEMBL368061


SMILES O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1
InChIKey POZFPYZCVYTCQZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 381.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Rat Histamine A pKi 6.85 7.04 7.24 ChEMBL
D1 DRD1 Bovine Dopamine A pKi 4.92 5.37 5.69 ChEMBL
D2 DRD2 Bovine Dopamine A pKi 6.13 6.82 7.16 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.3 8.47 9.3 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.39 5.88 6.55 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.58 5.69 5.8 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 9.3 9.3 9.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 5.84 6.98 7.82 ChEMBL