CHEMBL378669


SMILES CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1
InChIKey GPZGUIZYGOLWTO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 494.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D5 DRD5 Human Dopamine A pKi 7.28 7.28 7.28 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.49 6.49 6.49 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.09 6.09 6.09 ChEMBL
D1 DRD1 Human Dopamine A pKi 8.59 8.59 8.59 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.05 9.05 9.05 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.3 6.3 6.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database